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Tradipitant

CAS No. : 622370-35-8

產(chǎn)品活性：Tradipitant (VLY-686) is a neurokinin-1 (NK-1) antagonist.

研究領(lǐng)域：GPCR/G Protein  |  Neuronal Signaling

作用靶點(diǎn)：Neurokinin Receptor

In Vitro: Results reveal that Tradipitant ([³H]-LY686017) bind to sections of guinea pig brain with a distribution similar to that previously reported for NK-1 receptors. Areas with the highest density are the accessory olfactory nucleus, anteroventral thalamic nucleus, paraventricular hypothalamic nucleus central amygdaloid nucleus (lateral) and the medial amygdaloid nucleus (anterodorsal).

In Vivo: Autoradiography experiments reveal that intravenously administered Tradipitant ([³H]-LY686017) localizes in the guinea pig brain and has a distribution similar to that described for the NK-1 receptor using agonist or antagonist radioligands.

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