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Concizumab

CAS No. : 1312299-39-0

產(chǎn)品活性：Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that binds to the Kunitz-type protease inhibitor (KPI) 2 structural domain of TFPI, thereby blocking the interaction of this structural domain with the FXa active site. Concizumab can be used in the study of haemophilia.

研究領(lǐng)域：Others

作用靶點：Others

In Vitro: Concizumab increases thrombin peak in a concentration- dependent manner.

In Vivo: Concizumab (i.v./s.c.) blocks the TFPI interaction with the active site of FXa in cynomolgus monkeys.
＜ｍｅｔａ http-equiv="Content-Type" content="text/html; charset=utf-8" /> Pharmacokinetic parameters after intravenous or subcutaneous administration of Concizumab to cynomolgus monkeys.

Parameter	Unit	Estimate	%RSE
CLL	mL/h/kg	0.14	6.1
V1	mL/kg	33	34
V2	mL/kg	33	-
Q	mL/h/kg	0.12	16
F	%	93	7.7
Vmax	µg/h/kg	11	17
Km	µg/mL	0.54	52
t1/2(abs)	h	72	32

CL_L: the linear part of the clearance.
V1: the volume of the central compartment.
V2: the volume of the peripheral compartment.
V_max: the maximum amount of anti-TFPI cleared per time unit via binding to TFPI.
K_m: the concentration at which the target mediated elimination rate is 50% of the maximum value (Vmax).
T_1/2(abs): the absorption half-life, describing the rate of absorption after sc administration.
%RSE: residual standard error.

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