目錄:MedChemExpress LLC>>生化試劑>> Cilgavimab | MCE
CAS | 2420563-99-9 | 供貨周期 | 現(xiàn)貨 |
---|---|---|---|
規(guī)格 | 5 mg | 貨號 | HY-P99604 |
應用領域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
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CAS No. : 2420563-99-9
產(chǎn)品活性:Cilgavimab (AZD-1061; COV2-2130) is a humanized SARS-CoV-2-neutralizing monoclonal antibody, can compose monoclonal-antibody combination AZD7442 with Tixagevimab (HY-P99556). Cilgavimab shows protective action on mouse models of SARS-CoV-2 infection.
研究領域:Anti-infection
作用靶點:SARS-CoV
In Vitro: Cilgavimab and Tixagevimab simultaneously bind to distinct, nonoverlapping epitopes of the SARS-CoV-2 spike-protein (S) receptor-binding domain to potently neutralize the virus.
Cilgavimab exhibits potent monoclonal antibody neutralization activity, and human ACE2-blocking activity, with IC50s of 10-150 ng/mL, and shows binding ability to either trimeric S2Pecto protein or monomeric SRBD with IC50s of 0.1-10 ng/mL.
In Vivo: Cilgavimab (200 μg/mouse; i.p.; before SARS-CoV-2 injection) protects mice from weight loss and reduces the viral burden and levels of inflammation in the lungs.
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