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STX-0119

CAS No. : 851095-32-4

產(chǎn)品活性：STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC₅₀ of 74 μM.

研究領(lǐng)域：JAK/STAT Signaling  |  Stem Cell/Wnt

作用靶點：STAT

In Vitro: STX-0119 (10-50 μM; 24 h) inhibits STAT3 dimerization through a direct interaction with the STAT3 protein and not via the modulation of upstream regulators such as JAK in HEK293 and MDA-MB-468 cells.
STX-0119 (10-50 μM; 24 h) reduces the expression of STAT3 target proteins.

In Vivo: STX-0119 (160 mg/kg; oral gavage; daily for 4 days) inhibits SCC-3 tumor growth in mice.
The plasma concentration of STX-0119 (160 mg/kg; oral gavage) is maintained at >100 μg/mL (>260 μM), even at 8 h after administration.

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