目錄:MedChemExpress LLC>>生化試劑>> SRI-011381 hydrochloride | MCE
CAS | 2070014-88-7 | 純度 | 99.97% |
---|---|---|---|
分子量 | 365.94 | 分子式 | C??H??ClN?O |
供貨周期 | 現(xiàn)貨 | 規(guī)格 | 5 mg |
貨號 | HY-100347A | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
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CAS No. : 2070014-88-7
產(chǎn)品活性:SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.
研究領(lǐng)域:Stem Cell/Wnt | TGF-beta/Smad
作用靶點:TGF-beta/Smad
In Vitro: SRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression.
In Vivo: SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) hydrochloride partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice.
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