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WEHI-539 hydrochloride

CAS No. : 2070018-33-4

MCE 國(guó)際站：WEHI-539 hydrochloride

產(chǎn)品活性：WEHI-539 hydrochloride 是一種選擇性的 Bcl-XL 抑制劑，IC₅₀ 為 1.1 nM。

研究領(lǐng)域：Apoptosis

作用靶點(diǎn)：Bcl-2 Family

In Vitro: WEHI-539 hydrochloride is a selective inhibitor of Bcl-X_L. WEHI-539 augments NSC 241240 induced caspase 3/7 activity, PARP cleavage and annexin V labelling. WEHI-539 as a single agent causes noticeable PARP cleavage in Ovcar-4 (5 μM in Ovcar-4.) and Ovsaho (1 μM in Ovsaho) cells.

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