目錄:MedChemExpress LLC>>信號通路>> AGN-195183 | MedChemExpress
| CAS | 367273-07-2 | 純度 | 99.76% |
|---|---|---|---|
| 分子量 | 437.86 | 分子式 | C??H??ClF?NO? |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL |
| 貨號 | HY-16684 | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)。
CAS No. : 367273-07-2
MCE 國際站：AGN-195183
產(chǎn)品活性：AGN-195183 (IRX-5183) 是選擇性的 RARα 激動(dòng)劑，Kd 為 3 nM。AGN-195183 對 RARβ/γ 無活性。
研究領(lǐng)域：Metabolic Enzyme/Protease | Vitamin D Related/Nuclear Receptor | Autophagy
作用靶點(diǎn)：RAR/RXR | Autophagy
In Vitro: AGN-195183 (IRX-5183; Compound 4) inhibits the growth of breast cancer cell lines, and is inactive in an in vivo model of topical irritation.AGN-195183 and ATRA inhibit growth of the human breast cancer cell lines, T-47D and SK-BR-3. AGN-195183 does not cause the topical irritation induced by the RARa-selective retinoid, Am-580. AGN-195183 is currently in Phase I/IIA clinical trials in cancer patients.
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