目錄:MedChemExpress LLC>>信號通路>> PNU-282987 | MedChemExpress
| CAS | 123464-89-1 | 純度 | 99.70% |
|---|---|---|---|
| 分子量 | 301.21 | 分子式 | C??H??Cl?N?O |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL |
| 貨號 | HY-12560A | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
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CAS No. : 123464-89-1
MCE 國際站：PNU-282987
產(chǎn)品活性：PNU-282987 是一種有效的 α7 煙堿乙酰膽堿受體 (nAChR) 激動劑，EC50 為 154 nM。PNU-282987 也是 5-HT3 受體的功能性拮抗劑，IC50 為 4541 nM。PNU-282987 可用于中樞和外周神經(jīng)系統(tǒng)的研究。
研究領(lǐng)域：Membrane Transporter/Ion Channel | Neuronal Signaling | GPCR/G Protein
作用靶點：nAChR | 5-HT Receptor
In Vitro: PNU-282987 (Compound C7) displaces the R7 selective antagonist methyllycaconitine (MLA) from rat brain homogenates with a Ki of 27 nM.
PNU-282987 has α7 nAChR agonist activity with an EC50 of 154 nM.
PNU-282987 also has inhibition for the 5-HT3 receptor with an IC50 value of 4541nM.
In Vivo: PNU-282987 (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit.
PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner.
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