MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)。

Mitapivat

CAS No. : 1260075-17-9

MCE 國際站：Mitapivat

產(chǎn)品活性：Mitapivat (AG-348) 是一種口服有效的丙酮酸激酶 (pyruvate kinase) 變構(gòu)激活劑。Mitapivat 在廣泛的 PKLR 基因型中增加酶活性、蛋白質(zhì)穩(wěn)定性和 ATP 水平，具有恢復(fù)丙酮酸激酶缺乏的糖酵解途徑活性的潛力。Mitapivat 可用于丙酮酸激酶缺乏癥的研究。

研究領(lǐng)域：Metabolic Enzyme/Protease

作用靶點：Pyruvate Kinase

In Vitro: Mitapivat (0.1 nM-100 μM; 16 h) activates WT PK-R in RBCs from healthy donors.
Mitapivat (0.01 nM-10 μM; 16 h) promotes production of ATP in RBC cells in a dose-dependent manner.

In Vivo: Mitapivat (50 mg/kg; p.o.; twice daily for 21 days) improves anemia in a mouse model for β-thalassemia.

相關(guān)產(chǎn)品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Metabolism/Protease Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Glycolysis Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Anti-Cancer Metabolism Compound Library  |  Glucose Metabolism Compound Library  |  Targeted Diversity Library  |  Rare Diseases Drug Library  |  Heterocyclic Compound Library  |  TEPP-46  |  TEPC466  |  ML202  |  PKM2 activator 5  |  (Rac)-Etavopivat  |  PKM2 activator 3  |  PKM2-IN-3  |  PKM2/PDK1-IN-1  |  ZY-1  |  2,5-Anhydro-D-glucitol-1,6-diphosphate  |  PKR activator 3  |  Shikonin  |  Vitamin K5  |  PKM2 activator 2  |  PKM2-IN-1  |  PKR activator 4  |  FX-11  |  DASA-58  |  PKM2 activator 4  |  PKR activator 1  |  PKM2-IN-4  |  CIAC001  |  Tebapivat

熱門產(chǎn)品線：重組蛋白  |  化合物庫  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標(biāo)記物  |  寡核苷酸  |  抗體  |  點擊化學(xué)

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry