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Heparin sodium salt

CAS No. : 9041-08-1

MCE 國際站：Heparin sodium salt

產品活性：Heparin sodium salt (Sodium heparin) 是一種抗凝劑，可與 抗凝血酶III (ATIII) 可逆地結合，大大加快了ATIII使凝血酶因子IIa 和 Xa 失活的速度。Heparin sodium salt 顯著抑制外泌體-細胞相互作用。

研究領域：Metabolic Enzyme/Protease  |  Autophagy

作用靶點：Thrombin  |  Factor Xa  |  Autophagy

In Vitro: Heparin is a potent anticoagulant drug based on its ability to accelerate the rate at which antithrombin inhibits serine proteases in the blood coagulation cascade. Heparin and the structurally related heparan sulfate are complex linear polymers comprised of a mixture of chains of different length, having variable sequences. Heparin interactes most tightly with peptides containing a complementary binding site of high positive charge density. Heparin and heparan sulfate predominantly exhibit linear helical secondary structures with sulfo and carboxyl groups displayed at defined intervals and in defined orientations along the polysaccharide backbone. Heparin resembles DNA as both are highly charged linear polymers that behave as polyelectrolytes. Heparin is believed to function as an anticoagulant primarily through its interaction with AT III by enhancing AT-III-mediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin binds to AT III and thrombin in a ternary complex, increasing the bimolecular rate constant for the inhibition of thrombin by a factor of 2000. Heparin is principally located in the granules of tissue mast cells that are closely associated with the immune response. Heparin makes numerous contacts with both FGF-2 and FGFR-1 stabilizing FGF–FGFR binding. Heparin also makes contacts with the FGFR-1 of the adjacent FGF–FGFR complex, thus seeming to promote FGFR dimerization.

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