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AZD0156

CAS No. : 1821428-35-6

MCE 國際站：AZD0156

產品活性：AZD0156 是一種有效的，選擇性的和口服活性的 ATM 抑制劑，IC₅₀ 為 0.58 nM。AZD0156 抑制 ATM 介導的信號轉導，防止 DNA 損傷檢查點激活，破壞 DNA 損傷修復，并誘導腫瘤細胞凋亡 (apoptosis)。

研究領域：Cell Cycle/DNA Damage  |  PI3K/Akt/mTOR  |  Apoptosis

作用靶點：ATM/ATR  |  Apoptosis

In Vitro: AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells.

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