MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)。

SH5-07

CAS No. : 1456632-41-9

MCE 國(guó)際站：SH5-07

產(chǎn)品活性：SH5-07 是一種基于異羥肟酸的 Stat3 抑制劑，在體外實(shí)驗(yàn)中的 IC₅₀ 值為 3.9 μM。

研究領(lǐng)域：JAK/STAT Signaling  |  Stem Cell/Wnt

作用靶點(diǎn)：STAT

In Vitro: SH5-07 is a hydroxamic acid analog of BP-1-102. SH5-07 dose-dependently inhibits Stat3 activity with an IC₅₀ of 3.9±0.6 μM in in vitro assay. It preferentially inhibits Stat3:Stat3 DNA-binding activity, ahead of inhibiting Stat1:Stat3 activity, with minimal effects on Stat1:Stat1 activity. SH5-07 binds Stat3, disrupts Stat3 association with growth factor receptor, and thereby inhibits Stat3 phosphorylation. It induces antitumor cell effects against malignant cells harboring constitutively-active Stat3. SH5-07 inhibits the expression of known Stat3-regulated genes. Bcl-2, Bcl-xL, c-Myc, Survivin, Cyclin D1 and Mcl-1 expression is reduced in response to 24 h, 5 μM SH5-07 treatment.

In Vivo: Tail vein injection or oral gavage delivery of SH5-07 or SH4-54 inhibits growth of 90-150 mm³ established subcutaneous mouse xenografts of human glioma (U251MG) and breast (MDA-MB-231) tumors that harbor aberrantly-active Stat3, associated with decreased c-Myc, Mcl-1 and Cyclin D1 expression. No significant changes in body weights, blood cell counts, or the gross anatomy of organs, or obvious signs of toxicity are observed.

相關(guān)產(chǎn)品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  JAK/STAT Compound Library  |  Kinase Inhibitor Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Small Molecule Immuno-Oncology Compound Library  |  Anti-Aging Compound Library  |  Differentiation Inducing Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Anti-Obesity Compound Library  |  Transcription Factor-Targeted Library  |  Targeted Diversity Library  |  Anti-Liver Cancer Compound Library   |  Anti-Prostate Cancer Compound Library  |  Cancer Stem Cells Compound Library  |  Highly Selective Inhibitors Library  |  8α-Tigloyloxyhirsutinolide 13-O-acetate  |  Stafia-1-dipivaloyloxymethyl ester  |  Niclosamide monohydrate  |  STAT6-IN-2  |  15-keto-Prostaglandin E2  |  Brevilin A  |  STAT3 degrader-1  |  NSC-370284  |  Broussonin E  |  RO8191  |  Eflepedocokin alfa  |  Morusin  |  STAT3-IN-13  |  DG-8  |  Antitumor agent-73  |  1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea  |  IST5-002  |  JAK-STAT-IN-1  |  Delphinidin chloride  |  SC-43  |  Astaxanthin  |  LLL12  |  MNK8  |  Syk-IN-6  |  STAT5-IN-2  |  (+)-Ochromycinone  |  STAT3-IN-11  |  HP590  |  FLLL32  |  SI-109

熱門產(chǎn)品線：重組蛋白  |  化合物庫(kù)  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標(biāo)記物  |  寡核苷酸  |  抗體  |  點(diǎn)擊化學(xué)

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry