MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)。

AGI-24512

CAS No. : 2201066-53-5

MCE 國際站：AGI-24512

產(chǎn)品活性：AGI-24512 是一種蛋氨酸腺苷轉(zhuǎn)移酶 2α (MAT2A) 抑制劑，IC₅₀ 為 8 nM。AGI-24512 觸發(fā) DNA 損傷反應。AGI-24512 可阻斷 MTAP 缺失的癌細胞體外增殖。AGI-24512可用于抗癌研究。

研究領(lǐng)域：Epigenetics  |  Metabolic Enzyme/Protease

作用靶點：Methionine Adenosyltransferase (MAT)

In Vitro: AGI-24512 (0-1 μM; 96 hours) blocks proliferation of MTAP (methylthioadenosine phosphorylase)-deleted HCT116 cancer cells with an IC₅₀ of 100 nM.
?AGI-24512 significantly increases in γH2AX-positive cells in MTAP^-/- HCT116 cells.
?AGI-24512 inhibits PRMT5-mediated SDMA marks with an IC₅₀ of 95 nM in MTAP^-/- cells.
?AGI-24512 leads to a dose-dependent decrease in SAM (S-adenosylmethionine) levels in the HCT116 MTAP-null cell, with an IC₅₀ of 100 nM.

In Vivo: AGI-24512 shows poor oral absorption and a short half-life in rats.

相關(guān)產(chǎn)品：Bioactive Compound Library Plus  |  AGI-25696  |  MAT2A inhibitor 2  |  MAT2A-IN-10  |  MAT2A inhibitor 3  |  AG-270  |  MAT2A inhibitor 4  |  FIDAS-5  |  PF-9366  |  MAT2A-IN-12  |  MAT2A inhibitor 1  |  MAT2A-IN-9

熱門產(chǎn)品線：重組蛋白  |  化合物庫  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標記物  |  寡核苷酸  |  抗體  |  點擊化學

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry