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Carboplatin

CAS No. : 41575-94-4

MCE 國(guó)際站：Carboplatin

產(chǎn)品活性：Carboplatin (NSC 241240) 是一種 DNA 合成 抑制劑，其與 DNA 結(jié)合，抑制復(fù)制和轉(zhuǎn)錄并誘導(dǎo)細(xì)胞死亡。Carboplatin (NSC 241240) 是順鉑的衍生物，是一種有效的抗癌劑。

研究領(lǐng)域：Cell Cycle/DNA Damage  |  Autophagy

作用靶點(diǎn)：DNA Alkylator/Crosslinker  |  Autophagy  |  DNA/RNA Synthesis

In Vitro: Carboplatin is an antitumor agent, with an increased DNA-binding activity in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts.
Carboplatin is less cytotoxic to human ovarian cells such as A2780, SKOV3, IGROV1 and HX62 than 17-AAG, with IC₅₀s of 6.177, 12.442, 2.233 and 116.068 μM, respectively. Moreover, Carboplatin does not affect HSP90 or change the activity of 17-AAG to inhibit HSP90.
Carboplatin reduces the viability of Brca1 (IC₅₀, 3.4 μM) and Brca2 cells (IC₅₀, 1.9 μM). Carboplatin (25 μM) combined with ABT-888 also shows an apoptotic effect in BRCA1 cells.

In Vivo: Carboplatin (60 mg/kg, i.p.) shows a modest effect on the tumor, but significantly inhibits tumor growth in combination with 17-AAG in mice bearing A2780 human ovarian cancer xenografts.
Carboplatin (25 mg/kg, p.o.) combined with ABT-888 delays tumor growth in Brca2 xenografts.

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