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Tivozanib

CAS No. : 475108-18-0

MCE 國(guó)際站：Tivozanib

產(chǎn)品活性：Tivozanib (AV-951; KRN951) 是一種有效的、選擇性的、具有口服活性的 VEGFR 酪氨酸激酶 抑制劑，對(duì) VEGFR-1、VEGFR-2、VEGFR-3的 IC₅₀ 值分別為 0.21、0.16、0.24 nM。Tivozanib 抑制腫瘤組織中的血管生成和血管通透性，并顯示出抗腫瘤活性。Tivozanib 具有研究轉(zhuǎn)移性腎細(xì)胞癌 (RCC) 的潛力。

研究領(lǐng)域：Protein Tyrosine Kinase/RTK

作用靶點(diǎn)：VEGFR

In Vitro: Tivozanib inhibits the phosphorylation of VEGFR-1, VEGFR-2 and VEGFR-3.

In Vivo: Tivozanib (1 mg/kg; p.o.; 14 days) suppresses the development of CNV lesions and leds to a significant regression of established CNV, reducing the affected areas by 67.7%.

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