目錄:MedChemExpress LLC>>信號通路>> RG7112 | MedChemExpress (MCE)
| CAS | 939981-39-2 | 純度 | 99.91% |
|---|---|---|---|
| 分子量 | 727.78 | 分子式 | C??H??Cl?N?O?S |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL |
| 貨號 | HY-10959 | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)。
CAS No. : 939981-39-2
MCE 國際站：RG7112
產(chǎn)品活性：RG7112 是有效的、選擇性的、第一個(gè)用于臨床的、可口服的、可透過血腦屏障的、 MDM2-p53 抑制劑，IC50 值為 18 nM，結(jié)合到MDM2 的KD 值為 11 nM.
研究領(lǐng)域：Apoptosis | Metabolic Enzyme/Protease
作用靶點(diǎn)：MDM-2/p53 | E1/E2/E3 Enzyme
In Vitro: RG7112 (0-5 μM) stabilizes wild-type p53 and induces p53 signaling in cancer cells. RG7112 effectively activates p53 functions in cancer cells.
In Vivo: RG7112 (25-200 mg/kg, single oral dose) activates p53 pathway and induces apoptosis in tumor cells in vivo.
?RG7112 (100 mg/kg, gavage once per day, 5 days/week for 3 weeks ) reduces tumor growth rate and increases survival in GBM models.
相關(guān)產(chǎn)品：Clinical Compound Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Metabolism/Protease Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | CNS-Penetrant Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Oxygen Sensing Compound Library | Ubiquitination Compound Library | Ferroptosis Compound Library | Pyroptosis Compound Library | Orally Active Compound Library | Chemical Probe Library | Glutamine Metabolism Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Transcription Factor-Targeted Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Protein-protein Interaction Inhibitor Library | Highly Selective Inhibitors Library | TAK-243 | Nutlin-3a | Minocycline hydrochloride | Pifithrin-α hydrobromide | Subasumstat | GSK3326595 | Idasanutlin | Navtemadlin | Eprenetapopt | ML-792 | CBL0137 hydrochloride | Mezigdomide | PYR-41 | MD-224 | Amifostine | UC2288 | 2-D08 | Siremadlin | Cbl-b-IN-1 | Pifithrin-α, p-Nitro, Cyclic | C25-140 | Ginkgolic Acid | Milademetan | NSC319726 | Indole-3-carbinol | HOIPIN-8 | LS-102 | PRT4165 | RB-3
熱門產(chǎn)品線：重組蛋白 | 化合物庫 | 天然產(chǎn)物 | 熒光染料 | PROTAC | 同位素標(biāo)記物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
(空格分隔,最多3個(gè),單個(gè)標(biāo)簽最多10個(gè)字符)
3
化工儀器網(wǎng)