MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)。

Vilazodone Hydrochloride

CAS No. : 163521-08-2

MCE 國際站：Vilazodone Hydrochloride

產(chǎn)品活性：Vilazodone Hydrochloride (EMD 68843 Hydrochloride) 是 5-羥色胺轉(zhuǎn)運(yùn)體 (SER) 的抑制劑和 5-HT_1A 受體的部分激動劑。

研究領(lǐng)域：GPCR/G Protein  |  Neuronal Signaling

作用靶點(diǎn)：5-HT Receptor  |  Serotonin Transporter

In Vivo: Administration of 5-HT_1A receptor agonists produce a characteristic behavioral syndrome that includes changes in posture, hind limb reduction, head weaving, tremors, forepaw treading, and straub tail. In the rat ultrasonic vocalizations test, stress-induced vocalizations are inhibited by Vilazodone Hydrochloride (EMD 68843 Hydrochloride) (55 mg/kg po) at 120 and 210 min post dose. Vilazodone Hydrochloride (EMD 68843 Hydrochloride) (20-40 mg/kg ip), administered acutely or prophylactically (1 week prior to behavioral testing), attenuated stress induces potentiated startle but has no effect on stress potentiated anxiety response in the elevated plus maze. Interestingly, a lower dose of 10 mg/kg of Vilazodone Hydrochloride (EMD 68843 Hydrochloride) has the opposite effect in the startle response, indicating a somewhat unexplained bidirectional effect, and all doses produce a potentiation of the startle-induced stress response possibly suggestive of an anxiogenic-like response. Vilazodone Hydrochloride (EMD 68843 Hydrochloride) also represents another option for the treatment of MDD.

相關(guān)產(chǎn)品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Orally Active Compound Library  |  Neurotransmitter Receptor Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Anti-Alzheimer's Disease Compound Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Anti-Obesity Compound Library  |  Targeted Diversity Library  |  Antidepressant Compound Library  |  5-HT Receptor Compound Library  |  Human Metabolite Library  |  Coagulation and Anti-coagulation Compound Library  |  Heterocyclic Compound Library  |  Off-patent Drug Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Highly Selective Inhibitors Library  |  Highly Selective Activators Library  |  Chlorpromazine hydrochloride  |  Serotonin hydrochloride  |  Harmine  |  Puerarin  |  SCH-23390 hydrochloride  |  Sertraline hydrochloride  |  Desipramine hydrochloride  |  Fluoxetine hydrochloride  |  Imipramine hydrochloride  |  Paroxetine hydrochloride  |  PNU-282987  |  Scopolamine hydrobromide  |  Risperidone  |  Dihydroergotamine mesylate  |  GTS-21 dihydrochloride  |  Clozapine  |  Amitriptyline hydrochloride  |  Olanzapine  |  Thioridazine hydrochloride  |  Brexpiprazole  |  Aripiprazole  |  Duloxetine hydrochloride  |  SEP-363856 hydrochloride  |  Volinanserin  |  Ondansetron  |  Vortioxetine  |  Cisapride

熱門產(chǎn)品線：重組蛋白  |  化合物庫  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標(biāo)記物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds