目錄:MedChemExpress LLC>>信號通路>> Tovorafenib | MedChemExpress (MCE)
| CAS | 1096708-71-2 | 純度 | 99.89% |
|---|---|---|---|
| 分子量 | 506.29 | 分子式 | C??H??Cl?F?N?O?S |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL |
| 貨號 | HY-15246 | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)。
CAS No. : 1096708-71-2
MCE 國際站：Tovorafenib
產(chǎn)品活性：Tovorafenib (TAK-580, MLN 2480) 是一種可口服的，具有選擇性的廣譜的 Raf 抑制劑。
研究領(lǐng)域：MAPK/ERK Pathway
作用靶點：Raf
In Vitro: Tovorafenib (TAK-580, MLN 2480) has effect on reversing feedback activation of MEK in response to TAK-733, leading to more concerted MAPK pathway inhibition.
In Vivo: Tovorafenib (TAK-580, MLN 2480) inhibits MAPK pathway signaling in BRAF mutant and some RAS mutant preclinical cancer models at concentrations that are tolerated in vivo. TAK-580 (MLN 2480) is most potent in BRAF mutant melanoma models but also has single agent activity in some RAS mutant models. The combination of MLN2480 with TAK-733 inhibits the growth of a broader range of RAS mutant tumor models than single agent TAK-580 (MLN 2480), including primary human tumor xenograft models of melanoma and CRC.
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