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Esomeprazole sodium

CAS No. : 161796-78-7

MCE 國際站：Esomeprazole sodium

產(chǎn)品活性：Esomeprazole sodium ((S)-Omeprazole sodium) 是一種有效的具有口服活性質(zhì)子泵 (proton pump) 抑制劑，可通過抑制胃壁細(xì)胞中的 H⁺, K⁺-ATPase 來降低酸分泌，并可用于胃食管反流疾病的研究。Esomeprazole 是一種外泌體抑制劑，通過抑制 V-H⁺-ATPases 來阻斷外泌體的釋放。

研究領(lǐng)域：Membrane Transporter/Ion Channel  |  Anti-infection

作用靶點：Proton Pump  |  Bacterial

In Vitro: Esomeprazole (25-100 µM; 20 hours; MDA-MB-468 cells) treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification.

In Vivo: Esomeprazole (30-300 mg/kg; oral gavage; daily; for 19 or 11 days; C57BL/6J mice) treatment significantly inhibits the progression of fibrosis throughout the lungs of the animals. Esomeprazole also reduces circulating markers of inflammation and fibrosis.

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