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BPS Bioscience
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BPS Bioscience的蛋白酶篩選和檢測(cè)服務(wù)

Accelerate your drug discovery program with Protease Screening and Profiling Services from BPS Bioscience, Inc. Trust us to provide you with high quality data with fast turnaround time. Our team of experts along with our broad services portfolio makes it easy to:

Screen for inhibitors/targets using our panel of many different assays including Cathepsins, Caspases, Dipeptidyl Peptidases (DPPs), Deubiquitinases, and other Proteases
Select from IC50 determination and single point concentrations
Receive data within days of compound submission
Perform follow-up studies using the same proteins manufactured in-house
Get questions answered or project guidance in a time-efficient manner

Biochemical Assays:

Aspartic Proteases	Cysteine Proteases	Metalloproteases	Serine Proteases
BACE1	SARS-CoV-1 3C-like Protease (3CL)	ADAM17	CLP
Caspase-3	SARS-CoV-2 3C-like Protease (3CL)	MMP1	DPP3
Caspase-6	SARS-CoV-2 Papain-like Protease (PLPro)	MMP2	DPP4
Caspase-7	A20	MMP3	DPP7
Caspase-8	Ataxin-3	MMP7	DPP8
Caspase-9	Cathepsin B	MMP8	DPP9
Renin, activated	Cathepsin F	MMP9 (Q279R)	FAP
	Cathepsin L	MMP10	Furin
	Cathepsin S	MMP11	HCV1a (D168V)
	Cathepsin V	MMP12	HCV1b
	MALT1	MMP13	HCV1b (D168V)
	OTUD6Bc	MMP14	HCV1b (R155K)
	UCHL1		HCV1b (R155Q)
	UCHL3		HCV2a
	USP2		POP
	USP5		Protein C, activated
	USP7		TMPRSS2
	USP8
	USP10
	USP14

Note: Not all targets will have a commercially available reference control. Please inquire with our team if you need to furnish your own controls for specific targets.

Protease signaling pathways regulate a wide range of vital physiological processes, including digestion of food, lysosome and proteasome degradation, apoptosis, blood coagulation, and cell cycle regulation.

The dysregulation of protease activity can lead to pathologies such as arthritis and inflammatory diseases,cardiovascular disorders, cancer, osteoporosis, Alzheimer’s, and other neurological disorders. Several small molecule, protease inhibitor drugs are already on the market and many more are in development.

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