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Nutlin-3

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產(chǎn)品型號27711

品       牌BPS Bioscience

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更新時間：2023-12-19 22:38:58瀏覽次數(shù)：107次

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●Purchase●DescriptionCis-imidazolineanalogthatinhibitstheinteractionbetweenp53anditsnegativeregulatorMDM2(IC50=0
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Description

Cis-imidazoline analog that inhibits the interaction between p53 and its negative regulator MDM2 (IC50 = 0.09 μM). It induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. Nutlin-3 also inhibits the growth of human tumor xenografts in nude mice by 90% at a dose of 200 mg/kg.

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Synonyms
(±)–4–[4,5–Bis(4–chlorophenyl)–2–(2–isopropoxy–4–methoxy–phenyl)–4,5–dihydro–imidazole–1–carbonyl]–piperazin–2–one

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