MS-275 (Entinostat) 返回列表頁

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產(chǎn)品型號27011

品牌BPS Bioscience

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更新時間：2023-11-11 09:01:38瀏覽次數(shù)：101次

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●Purchase●DescriptionMS-275,alsoknownasEntinostat,isaninhibitorofhistonedeacetylases(HDACs)andpreferentiallyinhibitsHDAC1overHDAC3

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Description

MS-275, also known as Entinostat, is an inhibitor of histone deacetylases (HDACs) and preferentially inhibits HDAC1 over HDAC3. It does not inhibit HDAC8 (IC50 > 100 µM). It induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in vivo. Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs like adriamycin, inhibitors of PARPs, or inhibitors of Hsp90.

This product has been cited 2 times.

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Synonyms

MS-275, Entinostat

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