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CBL-B TR-FRET Assay Kit

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產品型號79575

品       牌BPS Bioscience

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更新時間：2023-11-12 23:06:26瀏覽次數(shù)：173次

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●Purchase●DescriptionHumanCasitasB-lineagelymphomaproto-oncogeneb(CBL-B)isanE3ubiquitin-proteinligasethatfunctionsasanegativeregulatorofT-cellactivation
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Purchase
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Description

Human Casitas B-lineage lymphoma proto-oncogene b (CBL-B) is an E3 ubiquitin-protein ligase that functions as a negative regulator of T-cell activation. It is a promising drug target in cancer immunotherapy. The CBL-B TR-FRET Assay Kit is designed to measure CBL-B auto-ubiquitination activity in a homogeneous 384 reaction format. It utilizes biotin-labeled Ubiquitin and a terbium-labeled antibody recognizing the GST-tagged CBL-B protein to complete the TR-FRET pairing. This FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications.

CBL-B TR-FRET

Figure: Illustration of Assay Principle

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Synonyms
UBE1, UBA1, ubcH5b, UBE2D2, E3 ubiquitin-protein ligase CBL-B, RING finger protein 56, CBL, CBLB, cbl TR-FRET

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