產(chǎn)品貨號：BD-PP1527

別名：Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)

產(chǎn)品名稱：TBK1/NAK (Phospho Ser172) Rabbit Polyclonal Antibody

類別：抗原抗體

基因名稱：TBK1 NAK

蛋白名稱：TBK1/NAK (Ser172)

Clonality：Polyclonal

推薦應(yīng)用：ELISA

反應(yīng)種屬：Human,Mouse

TBK1/NAK (phospho-Ser172)  rabbit pAb濃度：1 mg/ml

TBK1/NAK (phospho-Ser172)  rabbit pAb存儲緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

免疫原：Synthesized phosho peptide around human TBK1 and NAK (Ser172)

特異性：This antibody detects endogenous levels of Human Mouse TBK1/NAK (phospho-Ser172)

稀釋度：WB 1:1000-2000

預(yù)測分子量：80kDa

運輸及保存條件：-20°C/1 year

宿主：Rabbit

同種型：Rabbit,IgG

組織表達：Ubiquitous with higher expression in testis. Expressed in the ganglion cells, nerve fiber layer and microvasculature of the retina.

細胞定位：Cytoplasm . Upon mitogen stimulation or triggering of the immune system, TBK1 is recruited to the exocyst by EXOC2. .

信號通路：Toll_Like;RIG-I-like receptor;Cytosolic DNA-sensing pathway;

功能：

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with TIRAP, TANK and TRAF2. Part of a ternary complex consisting of TANK, TRAF2 and TBK1. Interacts with AZI2. Interacts with SIKE. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I, interactions are disrupted by the interaction between TBK1 and SIKE. Interacts with HCV NS3, a hepatitis C virus protein and with BDV P protein, a Borna disease virus protein.,tissue specificity:Ubiquitous with higher expression in testis.,

貨期：現(xiàn)貨

純化：The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

上海博盛龍生物科技有限公司專業(yè)從事生物實驗耗材的研發(fā)生產(chǎn)，致力于為客戶提供高品質(zhì)、低成本的優(yōu)質(zhì)實驗耗材。

博盛龍擁有十萬級無塵GMP車間1000平方米，倉儲間1500平方米，使用優(yōu)良工藝及表面處理技術(shù)，嚴格質(zhì)量保證。目前主營產(chǎn)品有：廣口試劑瓶、窄口試劑瓶、試劑瓶配套彩蓋、可立保存管、保存管配套彩蓋、方形血清瓶和PCR八聯(lián)排管等。

產(chǎn)品能夠廣泛應(yīng)用于分子生物學與細胞生物學、常規(guī)臨床檢驗、藥物篩選、基因組學與蛋白質(zhì)組學等領(lǐng)域。通過不斷積累與發(fā)展，博盛龍初步形成了產(chǎn)品質(zhì)量與客戶服務(wù)并重的服務(wù)模式，贏得了眾多合作客戶的信任，并達成戰(zhàn)略合作。

在未來，博盛龍將秉持初心，繼續(xù)前行，滿足客戶需求，致力于耗材的開發(fā)與生產(chǎn)。