商品信息

產(chǎn)品英文名稱	Human IL-17A Protein
產(chǎn)品中文名稱	17A（IL-17A）
別名	interleukin 17A, CTLA-8, IL17, IL17A

商品屬性

表達(dá)宿主	大腸桿菌
種屬	人
序列	氨基酸序列來(lái)源于：人IL-17A (Ile20-Ala155) (Q16552) 表達(dá)的蛋白片段。
活性	Testing in progress.
蛋白長(zhǎng)度	重組人IL-17A由136個(gè)氨基酸組成，預(yù)測(cè)分子量為15.7 KD。
純度	> 98% ，使用SDS-PAGE檢測(cè)
特點(diǎn)&優(yōu)勢(shì)	通過(guò)LAL法測(cè)定，每微克蛋白里內(nèi)毒素含量<0.1>
產(chǎn)品形式	凍干粉，凍干緩沖液為無(wú)菌的20 mM Tris，50 mM NaCl，pH 8.0。
基因ID	3605
蛋白序列鏈接	/uniprotkb/Q16552/entry#sequences
使用中注意事項(xiàng)	開蓋使用前，請(qǐng)先離心。本產(chǎn)品為凍干粉，推薦用該產(chǎn)品配套的Reconstitution Buffer進(jìn)行復(fù)溶，且濃度不低于100 µg/mL?？蛻艨筛鶕?jù)后續(xù)的實(shí)驗(yàn)需求，進(jìn)行進(jìn)一步的稀釋。
保存建議	本產(chǎn)品為凍干粉形式，建議：將凍干粉產(chǎn)品保存于-20℃以下的干燥環(huán)境中。本產(chǎn)品溶解之后，可在4℃保存2-7天，長(zhǎng)期使用請(qǐng)置于-20℃以下。為長(zhǎng)期保存，推薦添加載體蛋白（0.1% HSA或者BSA），并酌情分裝保存，避免反復(fù)凍融。
運(yùn)輸條件	冰袋運(yùn)輸（藍(lán)冰）
警告	本文列出的產(chǎn)品僅供研究使用，不適用于人類或臨床診斷。我們產(chǎn)品所推薦應(yīng)用，不是建議使用我們的產(chǎn)品去違反任何或許可證。對(duì)于使用本產(chǎn)品可能發(fā)生的侵權(quán)或其他違規(guī)行為，我們不承擔(dān)任何責(zé)任。

附加信息

背景

Interleukin-17A (IL-17A), also known as CTLA-8, belongs to the IL-17 cytokine family. IL-17A is expressed in memory Th17 cells and is a product of memory CD4+T cells. In addition to Th17 cells, IL-17A can also be produced by various immune cells, including CD8+T cells γδ T cells, natural killer T (NKT) cells, monocytes, and neutrophils. IL-17A plays a crucial role in the host's defense mechanisms against many bacterial and fungal pathogens, as well as in allergic and autoimmune responses. IL-17A plays a role in viral infection by promoting neutrophil inflammation. IL-17A is a homodimeric cytokine with similar biological activity to IL-17F. IL-17A and IL-17RA have high affinity binding, and IL-17RA is essential for the biological activity of IL-17A. IL-17A cannot bind to T cells, B cells, and myeloid cells lacking IL-17RA. IL-17A is associated with various autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma, and psoriasis. IL-17A also plays a pathogenic role in cancer. During tumor development, IL-17A recruits bone marrow-derived suppressor cells (MDSCs) to suppress anti-tumor immunity. IL-17A also promotes tumor growth in vivo by inducing IL-6.

圖片及說(shuō)明