Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. It is one of the essential members of the nuclear lamina protein family. Its main function is to maintain the integrity of nuclear skeleton, as well as to participate in the cell proliferation and aging by affecting the chromosome distribution. gene expression, and DNA damage repair. The abnormal expression of lamin B1 is related to certain diseases, including neurological diseases [e.g. neural tube defects （NDTs）, adult-onset autosomal dominant leukodystrophy （ADLD）] and tumors （e.g. pancreatic cancer）. It is also a potential tumor marker as well as drug target.