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目錄:杭州斯達(dá)特生物科技有限公司>>蛋白>>細(xì)胞因子>> S0A6043Human OX40L/TNFSF4/CD252, His tag

Human OX40L/TNFSF4/CD252, His tag
  • Human OX40L/TNFSF4/CD252, His tag
參考價(jià) 850
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參考價(jià) 850
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  • 品牌 Starter/斯達(dá)特
  • 型號 S0A6043
  • 廠商性質(zhì) 生產(chǎn)商
  • 所在地 南京市
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更新時(shí)間:2025-07-15 17:15:59瀏覽次數(shù):46評價(jià)

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Human OX40L/TNFSF4/CD252, His tag

OX40L is the ligand for OX40 and is stably expressed on many antigen-presenting cells such as DC2s (a subtype of dendritic cells), macrophages, and activated B lymphocytes. The ligation of OX40-OX40L is a source of survival signal for T cells and enables the development of memory T cells. Signaling through these two molecules also leads to polarization towards Th2 immune response even in an environment with low levels of IL-4 cytokine. OX40L is also present on the surface of many non-immune cells, for example, endothelial cells and smooth muscle cells. The surface expression of OX40L is induced by many pro-inflammatory mediators, such as TNF-α, e.g. produced by mast cells, IFN-γ and PGE2. Various single-nucleotide polymorphisms (SNPs) of the OX40L gene have been identified. For some of them association with systemic lupus erythematosus has been reported.

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