Rabbit Anti-Nrf2

Rabbit Anti-Nrf2
Cat. Number: by-1074R
Quantity
size:
0.1ml （1mg/1ml, Lyophilized or Liquid. Buffer = 0.01M PBS, pH 7.4 with 10 mg/ml
BSA and 0.1% Sodium azide. Reconstitute with 0.1ml sterile distilled water.）
Background: Transcription activator that binds to antioxidant response （ARE） elements in the
promoter regions of target genes. Important for the coordinated up-regulation of
genes in response to oxidative stress. May be involved in the transcriptional
activation of genes of the beta-globin cluster by mediating enhancer activity of
hypersensitive site 2 of the beta-globin locus control region. [SUBUNIT]
Heterodimer. May bind DNA with an unknown protein. Interacts with KEAP1.
Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1.
[SUBCELLULAR LOCATION] Cytoplasm, cytosol. Nucleus. Note=Cytosolic under
unstressed conditions, translocates into the nucleus upon induction by electrophilic
agents. Belongs to the bZIP family. CNC subfamily.
Also known
as:
Nuclear factor-E2 related factor2; Nrf-2; HEBP1; NF E2 related factor 2; NFE2
related factor 2; NFE2L2; Nrf 2; Nuclear factor erythroid 2 related factor 2; Nuclear
factor erythroid derived 2 like 2.
Specificity: • Rabbit Polyclonal IgG, affinity purified by Protein A.
• Reacts with: hu, mo, rat, cow, dog, Rb, hrs, chk
• Immunogen: KLH conjugated synthetic peptide derived from human Nrf2
C-terminus.
• Predicted molecular weight: 68kDa
Application: WB=1:100-1000 ELISA=1:1000-5000 IP=1:20-200 IHC-P=1:100-1000
IHC-F=1:100-1000 IF=1:100-1000
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The Lyophilized or Liquid
antibody is stable at room temperature for at least one month and for greater than a year when kept at -20
°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at
least two weeks at 2-4 °C.
Important Note: This product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.www.sbswkj.com