Dextran Sulfate Sodium Salt（DSS）葡聚糖硫酸鈉鹽 MW:36000~50000

產(chǎn)品描述

結(jié)腸炎建模DSS葡聚糖硫酸鈉鹽（Dextran sulfate，DSS）是葡聚糖的聚陰離子衍生物，其中含硫量 約為 17%，相當(dāng)于葡聚糖分子的每個(gè)葡萄糖殘?zhí)侵衅骄?/span>1.9個(gè)硫酸基團(tuán)。DSS具有幾個(gè)特點(diǎn)：1）聚陰離子復(fù)合物，可溶 于水，形成無色水溶液；2）純度高，且具有良好的穩(wěn)定性；3）可被自然降解。

炎癥性腸炎（IBD）是一種慢性、易復(fù)發(fā)的胃腸道感染，會(huì)提升腸道腫瘤發(fā)生的危險(xiǎn)性，主要包括 UC 和克羅恩病(Crohn disease, CD)。自 1985年第一次報(bào)道采用葡聚糖硫酸鈉(dextran sulphate sodium, DSS)制備出倉鼠潰瘍性結(jié)腸炎模型以來，已有大量研究證明 DSS 結(jié)腸炎模型與人類潰瘍性結(jié)腸炎相似。DSS結(jié)腸炎模型的組織學(xué)特點(diǎn)、臨床表現(xiàn)、發(fā)病部位和細(xì)胞因子增殖情況都與人類潰瘍性結(jié)腸炎(ulcerative colitis, UC)極為相似。該模型的造模條件和操作方法簡(jiǎn)單，造價(jià)便宜，重復(fù)性好，便于掌握和推廣；可根據(jù)實(shí)驗(yàn)?zāi)康恼{(diào)整 DSS 濃度和給藥時(shí)間，建立急性、慢性和急慢性交替性模型。

產(chǎn)品性質(zhì)

溶解方法

溶于水（100 mg/ml 澄清或者輕微模糊的黃色溶液）。具體使用濃度需根據(jù)造模類型，參考相關(guān)文獻(xiàn)或通過預(yù)實(shí)驗(yàn)摸索確定。

運(yùn)輸與保存方法

室溫運(yùn)輸與保存，有效期2年。

注意事項(xiàng)

1）為了您的安全和健康，請(qǐng)穿實(shí)驗(yàn)服并戴一次性手套操作。

2）本產(chǎn)品僅用于科研用途，禁止用于人身上。

3）DSS是葡聚糖聚合物，分子量是平均分子量，每個(gè)批次之間會(huì)存在分子量的差異，而分子量對(duì)結(jié)腸炎造模有影響。通常批次間比較穩(wěn)定，但少部分也會(huì)存在差異。建議客戶根據(jù)實(shí)驗(yàn)需求，購買足夠的同一批次的產(chǎn)品，或者使用批次之前進(jìn)行預(yù)實(shí)驗(yàn)。

客戶發(fā)表文獻(xiàn)（部分統(tǒng)計(jì)）

[1] Li Zhao, Fei Wang,Zhengwei Cai,et al.Improving drug utilization platform with injectable mucoadhesive hydrogel for treating ulcerative colitis[J].chemical engineering journal.424(2021)130464.IF=16.744

[2] Lingjun Tong, Haining Hao, Zhe Zhang,et al.Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota[J].Theranostics.2021; 11(17): 8570-8586 IF=11.556

[3] Li, Y., Dong, J., Xiao, H., Zhang, S., Wang, B., Cui, M., & Fan, S. Gut commensal derived-valeric acid protects against radiation injuries. Gut Microbes,.2020 .1–18.IF=10.245

[4] Jingjing Gan, Yuxiao Liu, Lingyu Sun,et al.Orally administrated nucleotide-delivery particles from microfluidics for inflammatory bowel disease treatment[J].Applied Materials Today.2021 Dec;25:101231 IF=10.041

[5] JialiDong,YuanLi,HuiwenXiao,et al.Oral microbiota affects the efficacy and prognosis of radiotherapy for colorectal cancer in mouse models[J].Cell reports.2021, 109886.IF=9.423

[6] Hao H,  Zhang X,  Tong L,  Liu Q,et al.Lactobacillus plantarumEffect of Extracellular Vesicles Derived From  Q7 on Gut Microbiota and Ulcerative Colitis in Mice[J].Frontiers in Immunology.2021.777147 .IF=7.561

[7] Yaohua Fan,Yanqun Fan,Kunfeng Liu,et al.Edible Bird’s Nest Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in C57BL/6J Mice by Restoring the Th17/Treg Cell Balance[J].Frontiers in Pharmacology.2021.632602.IF=7.561

[8] Jia-Rong Huang, Sheng-Te Wang, Meng-Ning Wei,et al.Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer[J].Frontiers in Pharmacology.2020.586885. IF=7.561

[9] Mengmeng Xu, Ying Kong, Nannan Chen,et al.Identification of Immune-Related Gene Signature and Prediction of CeRNA Network in Active Ulcerative Colitis[J].Frontiers in Immunology.2022; 13: 855645. IF=7.561

[10] Gao X, Fan W, Tan L, et al. Soy isoflavones ameliorate experimental colitis by targeting ERα/NLRP3 inflammasome pathways[J]. The Journal of Nutritional Biochemistry, 2020, 83.IF=6.048

HB221107