10GTX002GaTx2

GaTx2 

Selective blocker of ClC2 (CLCN2) chloride channels

氯離子通道蛋白2（CLCN2、CLC2）選擇性阻斷劑

GaTx2 (gating modifier of anion channels 2) was isolated from the venom of Leiurus quinquestriatus hebraeus.  is the most potent peptide inhibitor of ClC-2 (CLCN2) chloride channel ever described. K_d value is close to 20 pM. slows ClC-2 activation but without altering channel conductance. The effect is voltage-dependent. This inhibitory effect was highlighted on rabbit ClC-2 channels expressed in oocytes. It has no effect on ClC-0, ClC-1, ClC-3, ClC-4, CFTR, GABA_C, Xenopus Cl_Ca, Shaker B or Kv1.2 channels. Structurally,  is composed of two β-strands and one α-helix. This peptide is also called Leiuropeptide II. Bears 89, 93 and 96% identity with OdK1, neurotoxin PO1 and leiuropeptide III, respectively.

技術(shù)資料

氨基酸序列：

H-Val-Ser-Cys³-Glu-Asp-Cys⁶-Pro-Asp-His-Cys¹⁰-Ser-Thr-Gln-Lys-Ala-Arg-Ala-Lys-Cys¹⁹-Asp-Asn-Asp-Lys-Cys²⁴-Val-Cys²⁶-Glu-Pro-Ile-OH

二硫鍵： Disulfide bonds between Cys³-Cys¹⁹, Cys⁶-Cys²⁴, and Cys¹⁰-Cys²⁶

長(zhǎng)度 (aa)：29

分子式： C₁₂₅H₁₉₉N₃₉O₄₇S₆   

分子量： 3191.25 Da

外觀： White lyophilized solid

可溶性：water and saline buffer

CAS 號(hào)：not available

來源：Synthetic 

純度： > 98 %

產(chǎn)品信息