12HTX001Hainantoxin-IV（海南捕鳥蛛毒素-IV）

 Hainantoxin-IV（海南捕鳥蛛毒素-IV） 

Selective blocker of TTX-S VGSC(電壓門控鈉離子通道TTX-S選擇性阻斷劑)

Hainantoxin-IV (HNTX-IV) is a peptide that was originally isolated from the venom of the Chinese bird spiderOrnithoctonus hainana Liang (Selenocosmia hainana Liang). It has been reported that this peptide is a potent antagonist of tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels (VGSCs). Hainantoxin-IV binds to TTX-S with an IC₅₀value of 34 nM in adult rat dorsal root ganglion (DRG) neurons. Tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels are not affected by Hainantoxin-IV. It probably interacts with the site 1 through a mechanism quite similar to that of TTX without affecting the activation and inactivation kinetics.

Hainantoxin-IV技術(shù)資料

氨基酸序列：

 Glu-Cys²-Leu-Gly-Phe-Gly-Lys-Gly-Cys⁹-Asn-Pro-Ser-Asn-Asp-Gln-Cys¹⁶-Cys¹⁷-Lys-Ser-Ser-Asn-Leu-Val-Cys²⁴-Ser-Arg-Lys-His-Arg-Trp-Cys³¹-Lys-Tyr-Glu-Ile-NH2  

二硫鍵： Disulfide bonds between Cys²-Cys¹⁷, Cys⁹-Cys²⁴, and Cys¹⁶-Cys³¹

長度 (aa)： 35  

分子式：C₁₆₆H₂₅₇N₅₃O₅₀S₆  

分子量： 3987.6 Da  

外觀：White lyophilized solid 

可溶性：water and saline buffer 

CAS 號(hào)：Not available 

來源：Synthetic  

純度：> 97%

產(chǎn)品信息