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APP抗體

抗原
Amyloid beta (A4) Precursor Protein (APP)
別名
APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, DmelCG7727, EG:65F1.5, appl, aaa, abeta, abpp, ad1, appi, ctfgamma, cvap, pn2, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Abpp, Adap, ... show more
APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, DmelCG7727, EG:65F1.5, appl, aaa, abeta, abpp, ad1, appi, ctfgamma, cvap, pn2, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp, app, wu:fj34d10, wu:fk65e12, zgc:85740 show less
抗原表位
其他選擇 AA 666-670
C-Term(105),N-Term (93),pThr668 (33),pThr743 (33),pSer730 (26),pSer198 (13),pTyr757 (13),AA 18-289 (11),Transcript Variant 1 (10),AA 44-63 (9),Tyr756 (9),AA 737-751 (8),AA 332-362 (7),AA 681-695 (7),Ser730 (7),Thr668 (7),AA 292-312 (6),AA 339-348 (6),Middle Region (6),AA 18-32 (4),AA 666-670 (4),AA 1-14 (3),AA 1-17 (3),AA 32-40 (3),AA 653-662 (3),AA 747-761 (3),Internal Region (3),Thr743 (3),AA 1-40 (2),AA 18-286 (2),AA 18-38 (2),AA 19-305 (2),AA 29-61 (2),AA 333-362 (2),AA 400-450 (2),AA 660-669 (2),AA 671-685 (2),AA 735-763 (2),AA 736-770 (2),Center (2),Soluble (2),AA 1-16 (1),AA 1-245 (1),AA 1-42 (1),AA 17-23 (1),AA 17-42 (1),AA 18-336 (1),AA 23-29 (1),AA 35-40 (1),AA 35-42 (1),AA 350-450 (1),AA 37-42 (1),AA 489-770 (1),AA 50-150 (1),AA 602-757 (1),AA 602-770 (1),AA 643-695 (1),AA 672-711 (1),AA 672-770 (1),Extracellular Domain (1),Glu11 (1),Glu3 (1),Leu310 (1),Thr435 (1),Wild Type (1),pTyr756 (1),pan (1),phosphorylated (1),pyroGlu11 (1)
適用
其他選擇 Human, Murine, Rat ((Rattus))
Human(713),Rat ((Rattus)) (322),Murine (288),Bovine (176),Dog (Canine) (168),Pig (Porcine) (161),Chicken (153),Rabbit (50),Guinea Pig (13),Monkey (13),Frog (4),Non Human Primates (2),Zebrafish (Danio rerio) (2),Horse (Equine) (1),Mammalian (1),Primate (1),Xenopus laevis (1)
宿主
其他選擇 Rabbit
Rabbit(510),Mouse (194),Goat (38),Chicken (6),Sheep (2)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
Biotin(28),FITC (25),HRP (23),Alexa Fluor 350 (15),Alexa Fluor 488 (15),Alexa Fluor 555 (15),Alexa Fluor 647 (15),Cy3 (15),Cy5 (15),Cy5.5 (15),Cy7 (15),PE (7),APC (5),Alkaline Phosphatase (AP) (5),Magnetic Particles (2),Sepharose (2)
應(yīng)用范圍
其他選擇 Immunofluorescence (IF), Western Blotting (WB)
Western Blotting (WB)(516),ELISA (245),Immunohistochemistry (IHC) (192),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (164),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (149),Immunofluorescence (IF) (71),Flow Cytometry (FACS) (68),Immunoprecipitation (IP) (47),Immunocytochemistry (ICC) (31),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (28),Immunohistochemistry (Frozen Sections) (IHC (fro)) (24),Enzyme Immunoassay (EIA) (17),Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (8),Dot Blot (DB) (7),Immunohistochemistry (Acetone-fixed) (IHC (af)) (2),Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2),Radioimmunoassay (RIA) (2),Proximity Ligation Assay (PLA) (1)
[Pubmed] 4 references available
規(guī)格 50 μg
發(fā)貨至 中國 (更改)
發(fā)貨時(shí)間 29至35個(gè)工作日

APP抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

顯示 隱藏
免疫原 peptide Sequence around amino acids 666~670 (A-V-T-P-E) derived from Human APP protein.
特異性 This antibody detects endogenous levels of total APP protein.
純化方法 Affinity Chromatography using epitope-specific immunogen.

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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別名 Amyloid beta A4 Protein / APP
背景 Amyloid beta precursor protein gene (ABPP) encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Multiple transcript variants encoding several different isoforms have been found for this gene. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in nonneuronal cells. Isoform APP751 is the most abundant form in T lymphocytes. ABPP is expressed in all fetal tissues examined with the highest levels in brain, kidney, heart and spleen with weak expression observed in liver, ABPP is induced during neuronal differentiation. In the adult brain, highest expression of ABPP gene is found in the frontal lobe of the cortex and in the anterior perisylvian cortex opercular gyri, moderate expression in the cerebellar cortex, the posterior perisylvian cortex opercular gyri and the temporal associated cortex. Weak expression is found in the striate, extra striate and motor cortices. Mutations in ABPP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).Synonyms: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II
基因ID 351
NCBI Accession NP_000475
UniProt P05067
研究領(lǐng)域 Neurology, Alzheimer's Disease

使用細(xì)節(jié)

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使用細(xì)節(jié)

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應(yīng)用備注 Western Blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 For Research Use only

貯存及處理

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貯存及處理

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濃度 1.0 mg/mL
緩沖液 PBS (without Mg2+ and Ca2+),?pH 7.4 containing 150?mM NaCl, 0.02?% Sodium Azide and 50?% Glycerol.
儲(chǔ)存液 Sodium azide
注意事項(xiàng) This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事項(xiàng) Avoid repeated freezing and thawing.
儲(chǔ)存條件 -20 °C
儲(chǔ)存方法 Store the antibody (in aliquots) at -20 °C.

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