利格列汀雜質(zhì)對照品全套有哪些

時(shí)間：2021/2/23閱讀：1040

利格列汀雜質(zhì)對照品全套有哪些

深圳遠(yuǎn)揚(yáng)化學(xué)技術(shù)有限公司可提供利格列汀坦項(xiàng)目申報(bào)所用全套雜質(zhì)，隨貨提供CoA證書，HNMR，MS，HPLC圖譜，純度符合申報(bào)要求，現(xiàn)貨庫存，交貨及時(shí)，并可根據(jù)客戶提供結(jié)構(gòu)式進(jìn)行利格列汀雜質(zhì)定制合成。

利格列汀化合物是商品名為利格列汀片藥物的主要成分，化學(xué)名為8-[（3R）-3-氨基-1-哌啶基]-7-(2-丁炔基-1)-3,7-二氫-3-甲基-1-[（4-甲基-2-喹唑啉基）甲基]-1H-嘌呤-2,6-二酮；臨床上該化合物合成的藥物是屬于一種新的有效的選擇性二肽基肽酶-4（DPP-4）抑制劑，可用于治療2型糖尿病。

藥理作用：利格列汀是二肽基肽酶4（DPP-4）抑制劑，DPP-4能夠降解腸促胰島素激素樣多肽-1（GLP-1）以及葡萄糖依賴性促胰島素多肽（GIP）。利格列汀能夠升高活性腸促胰島素激素的濃度，以葡萄糖依賴性的方式刺激胰島素釋放，降低循環(huán)中的胰高血糖素水平。

這兩種腸促胰島素激素都參與了葡萄糖穩(wěn)態(tài)的生理調(diào)節(jié)。一天中腸促胰島素分泌維持較低的基礎(chǔ)水平，進(jìn)餐后立即升高。在葡萄糖水平正?；蛏叩臈l件下，GLP-1和GIP能增加胰腺β-細(xì)胞胰島素的生物合成和分泌。此外，GLP-1還能減少胰腺α細(xì)胞的胰高血糖素分泌，肝葡萄糖排出量減少。

利格列汀雜質(zhì)對照品全套有哪些

利格列汀 CAS號：668270-12-0	Linagliptin
利格列汀雜質(zhì)1	7-(but-2-yn-1-yl)-8-((2-hydroxyethyl)amino)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione
利格列汀雜質(zhì)2	2-((R)-3-aminopiperidine-1-carbonyl)-N-((R)-1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)benzamide
利格列汀雜質(zhì)3 CAS號：886588-63-2	N-Phthalimide-linagliptin
利格列汀雜質(zhì)4 CAS號：1638744-06-5	Linagliptin Impurity S
利格列汀雜質(zhì)5	N1,N2-bis((R)-1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)phthalamide
利格列汀雜質(zhì)6	(R)-2-((1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamoyl)benzoic acid
利格列汀雜質(zhì)7	Linagliptin Diene Impurity
利格列汀雜質(zhì)8	(Z)-8-bromo-7-(3-bromobut-2-en-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione
利格列汀雜質(zhì)9	8-bromo-1,7-di(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H,7H)-dione
利格列汀雜質(zhì)10	(R)-tert-butyl (1-(1,7-di(but-2-yn-1-yl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamate
利格列汀雜質(zhì)11	(R)-8-(3-aminopiperidin-1-yl)-1,7-di(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H,7H)-dione
利格列汀雜質(zhì)12	8-bromo-3-methyl-7-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione
利格列汀雜質(zhì)13	(R)-tert-butyl (1-(3-methyl-7-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamate
利格列汀雜質(zhì)14	(R)-8-(3-aminopiperidin-1-yl)-3-methyl-7-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione
利格列汀雜質(zhì)15 CAS號：1446263-38-2	(R)-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-8-(piperidin-3-ylamino)-3,7-dihydro-1H-purine-2,6-dione
利格列汀雜質(zhì)16 CAS號：1803079-49-3	(R)-N-(1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)-2,2,2-trifluoroacetamide
利格列汀雜質(zhì)17 CAS號： 668270-11-9	(S)-Linagliptin
利格列汀雜質(zhì)18	7-(but-2-yn-1-yl)-8-(dimethylamino)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione
利格列汀雜質(zhì)19	N-(2-acetylphenyl)-2-(8-bromo-7-(but-2-yn-1-yl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)acetamide
利格列汀雜質(zhì)20	(R)-tert-butyl (1-(1-(2-((2-acetylphenyl)amino)-2-oxoethyl)-7-(but-2-yn-1-yl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamate
利格列汀雜質(zhì)21	(R)-N-(2-acetylphenyl)-2-(8-(3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)acetamide
利格列汀雜質(zhì)22	(R)-tert-butyl (1-(7-(but-2-yn-1-yl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamate
利格列汀雜質(zhì)23	(R)-8-(3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H,7H)-dione
利格列汀雜質(zhì)24	(S)-tert-butyl (1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamate
利格列汀雜質(zhì)25	(R)-7-(but-2-yn-1-yl)-8-(3-((7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)amino)piperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione
利格列汀雜質(zhì)26	Linagliptin Acetamide
利格列汀雜質(zhì)27	8-bromo-7-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione
利格列汀雜質(zhì)28	(R)-8-(3-aminopiperidin-1-yl)-7-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione
利格列汀雜質(zhì)29	(R)-1-((4-methylquinazolin-2-yl)methyl)piperidin-3-amine
利格列汀雜質(zhì)30	1-(2-(((4-methylquinazolin-2-yl)methyl)amino)phenyl)ethanone
利格列汀雜質(zhì)31	8-((2-acetylphenyl)amino)-7-(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H,7H)-dione
利格列汀雜質(zhì)32	8-((2-acetylphenyl)amino)-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione
利格列汀雜質(zhì)33 CAS號：93703-24-3	8-bromo-3-methyl-1H-purine-2,6(3H,7H)-dione
利格列汀雜質(zhì)34	7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione
利格列汀雜質(zhì)35	tert-butyl (7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)(piperidin-4-yl)carbamate
利格列汀雜質(zhì)36	(S)-1-(1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)urea
利格列汀雜質(zhì)37	(S)-N-(1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)acetamide
利格列汀雜質(zhì)38	8-((R)-3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-1-((4-((S)-2-(((R)-1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)amino)propyl)quinazolin-2-yl)methyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
利格列汀雜質(zhì)39	7-(but-2-yn-1-yl)-3-methyl-8-(methylamino)-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione
利格列汀雜質(zhì)40	8-ethoxy-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione
利格列汀雜質(zhì)41	8-((R)-3-aminopiperidin-1-yl)-7-((Z)-3-(((R)-1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)amino)but-2-en-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione
利格列汀雜質(zhì)42	8-bromo-3-methyl-1,7-bis((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione
利格列汀雜質(zhì)43 CAS號：88203-04-7	2-((2-acetylphenyl)amino)acetonitrile
利格列汀雜質(zhì)44 CAS號：666816-98-4	8-bromo-9-(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H,9H)-dione
利格列汀雜質(zhì)45	(R)-9-(but-2-yn-1-yl)-8-(3-(1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,9H)-dione
利格列汀雜質(zhì)46	8-bromo-9-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,9H)-dione
利格列汀雜質(zhì)47	(R)-8-(3-aminopiperidin-1-yl)-9-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,9H)-dione
利格列汀雜質(zhì)48	8-bromo-7-(but-2-yn-1-yl)-3-methyl-6-((4-methylquinazolin-2-yl)methoxy)-3,7-dihydro-2H-purin-2-one
利格列汀雜質(zhì)49	8-bromo-7-(but-2-yn-1-yl)-3-methyl-2-((4-methylquinazolin-2-yl)methoxy)-3H-purin-6(7H)-one
利格列汀雜質(zhì)50	(R)-2-(1-(7-(but-2-yn-1-yl)-3-methyl-6-((4-methylquinazolin-2-yl)methoxy)-2-oxo-3,7-dihydro-2H-purin-8-yl)piperidin-3-yl)isoindoline-1,3-dione
利格列汀雜質(zhì)51	(R)-2-(1-(7-(but-2-yn-1-yl)-3-methyl-2-((4-methylquinazolin-2-yl)methoxy)-6-oxo-6,7-dihydro-3H-purin-8-yl)piperidin-3-yl)isoindoline-1,3-dione
利格列汀雜質(zhì)52	(R)-8-(3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-6-((4-methylquinazolin-2-yl)methoxy)-3,7-dihydro-2H-purin-2-one
利格列汀雜質(zhì)53	(R)-8-(3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-2-((4-methylquinazolin-2-yl)methoxy)-3H-purin-6(7H)-one
利格列汀雜質(zhì)54	(R)-8-(3-aminopiperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-7-((4-methylquinolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione
利格列汀雜質(zhì)55	N-(2-acetylphenyl)-2-bromoacetamide
利格列汀雜質(zhì)56	tert-butyl ((3R)-1-(7-(but-2-yn-1-yl)-3-methyl-2-((4-methylquinazolin-2-yl)methoxy)-6-oxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamate
利格列汀雜質(zhì)57	8-((R)-3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-2-((4-methylquinazolin-2-yl)methoxy)-1,2,3,7-tetrahydro-6H-purin-6-one
利格列汀雜質(zhì)58	tert-butyl (R)-(1-(7-(but-2-yn-1-yl)-3-methyl-6-((4-methylquinazolin-2-yl)methoxy)-2-oxo-3,7-dihydro-2H-purin-8-yl)piperidin-3-yl)carbamate
利格列汀雜質(zhì)59	(R)-8-(3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-6-((4-methylquinazolin-2-yl)methoxy)-3,7-dihydro-2H-purin-2-one
利格列汀雜質(zhì)60	(R)-7-(but-2-yn-1-yl)-8-(3-hydroxypiperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione
利格列汀雜質(zhì)61	(R)-1-(1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)urea
利格列汀雜質(zhì)62	8-bromo-9-(but-2-yn-1-yl)-3-methyl-3,9-dihydro-1H-purine-2,6-dione

深圳遠(yuǎn)揚(yáng)化學(xué)技術(shù)有限公司可現(xiàn)貨供應(yīng)各種雜質(zhì)對照品，醫(yī)藥標(biāo)準(zhǔn)品：噁拉戈利雜質(zhì)，鄰乙酰水楊酸雜質(zhì)，頭孢唑啉鈉雜質(zhì)，氯美扎酮雜質(zhì)，巴多昔芬雜質(zhì)，美羅培南雜質(zhì)，頭孢丙烯雜質(zhì)，乙酰氯芬酸雜質(zhì)，尼美舒利雜質(zhì)，保泰松雜質(zhì)，沃拉帕贊雜質(zhì)，雷洛昔芬雜質(zhì)，甲氧氯普胺雜質(zhì)，匹多莫德雜質(zhì)，非洛地平雜質(zhì)，度他雄胺雜質(zhì)，甲巰咪唑雜質(zhì)，達(dá)格列凈雜質(zhì)，依美斯汀雜質(zhì)，帕羅西汀雜質(zhì)，阿法替尼雜質(zhì)，克唑替尼雜質(zhì)，阿莫沙平雜質(zhì)，貝那普利雜質(zhì)，阿折地平雜質(zhì)，伐昔洛韋雜質(zhì)，伊潘立酮雜質(zhì)，替莫唑胺雜質(zhì)，喹硫平雜質(zhì)，阿莫西林雜質(zhì)，左旋多巴雜質(zhì)，來那替尼雜質(zhì)，普瑞巴林雜質(zhì)，馬來酸桂哌齊特雜質(zhì)等，圖譜證書齊全，純度保證。

利格列汀雜質(zhì)對照品全套有哪些

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