B細(xì)胞淋巴瘤6（鼠單克隆抗體）

Bcl-6 B細(xì)胞淋巴瘤6（鼠單克隆抗體）

廣州健侖生物科技有限公司

彌漫大B細(xì)胞淋巴瘤是NHL中zui常見的類型，幾乎占所有病例的1/3。這類淋巴瘤占以前臨床上的“侵襲性”或“中高度惡性”淋巴瘤的大多數(shù)病例。彌漫大B細(xì)胞淋巴瘤正確的診斷需要血液病理學(xué)專家根據(jù)合適的活檢和B細(xì)胞免疫表型的證據(jù)而得出。近年多個(gè)多中心隨機(jī)對(duì)照臨床試驗(yàn)研究資料證明，其標(biāo)準(zhǔn)的一線治療方案應(yīng)當(dāng)是利妥昔單抗(Rituximab,R)+CHOP方案，并且通過增加方案的劑量密度，縮短療程間隙時(shí)間，從而獲得更好的療效，如R-CHOP14 方案。

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【產(chǎn)品介紹】

細(xì)胞定位：細(xì)胞核

克隆號(hào)：LN22

同型：IgG2b

適用組織：石蠟/冰凍

陽性對(duì)照：扁桃體

抗原修復(fù)：熱修復(fù)（EDTA）

抗體孵育時(shí)間：30-60min

Bcl-6 B細(xì)胞淋巴瘤6（鼠單克隆抗體）

分析
序列測(cè)定揭示了酵母基因組中大范圍的堿基組成變化。多數(shù)酵母染色體由不同程度的、大范圍的GC豐富DNA序列和GC缺乏DNA序列鑲嵌組成。這種GC含量的變化與染色體的結(jié)構(gòu)、基因的密度以及重組頻率有關(guān)。GC含量高的區(qū)域一般位于染色體臂的中部，這些區(qū)域的基因密度較高；GC含量低的區(qū)域一般靠近端粒和著絲粒，這些區(qū)域內(nèi)基因數(shù)目較為貧乏。Simchen等證實(shí)，酵母的遺傳重組即雙鏈斷裂的相對(duì)發(fā)生率與染色體的GC豐富區(qū)相耦合，而且不同染色體的重組頻率有所差別，較小的Ⅰ、Ⅲ、Ⅳ和Ⅸ號(hào)染色體的重組頻率比整個(gè)基因組的平均重組頻率高。
酵母基因組另一個(gè)明顯的特征是含有許多DNA重復(fù)序列，其中一部分為*相同的DNA序列，如rDNA與CUP1基因、Ty因子及其衍生的單一LTR序列等。在開放閱讀框或者基因的間隔區(qū)包含大量的三核苷酸重復(fù)，引起了人們的高度重視。因?yàn)橐徊糠秩祟愡z傳疾病是由三核苷酸重復(fù)數(shù)目的變化所引起的。還有更多的DNA序列彼此間具有較高的同源性，這些DNA序列被稱為遺傳豐余（genetic redundancy）。酵母多條染色體末端具有長度超過幾十個(gè)kb的高度同源區(qū)，它們是遺傳豐余的主要區(qū)域，這些區(qū)域至今仍然在發(fā)生著頻繁的DNA重組過程。遺傳豐余的另一種形式是單個(gè)基因重復(fù)，其中以分散類型zui為典型，另外還有一種較為少見的類型是成簇分布的基因家族。成簇同源區(qū)（cluster homology region，簡稱CHR）是酵母基因組測(cè)序揭示的一些位于多條染色體的同源大片段，各片段含有相互對(duì)應(yīng)的多個(gè)同源基因，它們的排列順序與轉(zhuǎn)錄方向十分保守，同時(shí)還可能存在小片段的插入或缺失。這些特征表明，成簇同源區(qū)是介于染色體大片段重復(fù)與*分化之間的中間產(chǎn)物，因此是研究基因組進(jìn)化的良好材料，被稱為基因重復(fù)的化石。染色體末端重復(fù)、單個(gè)基因重復(fù)與成簇同源區(qū)組成了酵母基因組遺傳豐余的大致結(jié)構(gòu)。研究表明，遺傳豐余中的一組基因往往具有相同或相似的生理功能，因而它們中單個(gè)或少數(shù)幾個(gè)基因的突變并不能表現(xiàn)出可以辨別的表型，這對(duì)酵母基因的功能研究是很不利的。所以許多酵母遺傳學(xué)家認(rèn)為，弄清遺傳豐余的真正本質(zhì)和功能意義，以及發(fā)展與此有關(guān)的實(shí)驗(yàn)方法，是揭示酵母基因組全部基因功能的主要困難和中心問題。

Bcl-6

我司還提供其它進(jìn)口或國產(chǎn)試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團(tuán)菌、化妝品檢測(cè)、食品安全檢測(cè)等試劑盒以及日本生研細(xì)菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產(chǎn)品。

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【公司名稱】 廣州健侖生物科技有限公司
【市場(chǎng)部】    楊永漢

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-103室

analysis
Sequencing revealed a wide range of changes in base composition in the yeast genome. Most yeast chromosomes by varying degrees, a wide range of GC-rich DNA sequence and GC lack of DNA sequence mosaic composition. This change in GC content is related to the structure of the chromosome, the density of the gene, and the frequency of recombination. GC-rich areas are generally located in the middle of the chromosome arm, the gene density of these areas is higher; GC low-lying areas are generally close to the omere and centromere, the number of genes in these areas is relatively poor. Simchen et al. Confirmed that the relative frequency of yeast genetic recombination, ie, double-strand breaks, is coupled with the GC rich region of chromosomes, and the recombination frequency differs between different chromosomes. The smaller recombination frequencies of chromosomes I, III, IV, and IX Higher than the average recombination frequency of the entire genome.
Another obvious feature of the yeast genome is that it contains many DNA repeats, some of which are identical DNA sequences, such as rDNA and CUP1 genes, Ty factors and their derived single LTR sequences. In the open reading frame or gene spacer contains a large number of trinucleotide repeats, aroused people's attention. Because part of the human genetic disease is caused by changes in the number of trinucleotide repeats. There are many more DNA sequences that have higher homology to each other, and these DNA sequences are called genetic redundancy. At the ends of yeast chromosomes, there are highly homologous regions of more than several dozen kb in length, which are the major areas of genetic redundancy that are still undergoing frequent DNA recombination processes to this day. Another form of genetic redundancy is a single gene duplication, of which the most typical type of dispersion, in addition there is a less common type is a cluster of gene clusters. Clustered homology regions (CHRs) are homologous large fragments of multiple chromosomes revealed by yeast genome sequencing. Each fragment contains multiple homologous genes corresponding to each other, and their arrangement order and transcription direction are very close Conservative, while there may be small insertions or deletions. These features indicate that clustered homology regions are intermediate products between the repetition and complete differentiation of large chromosome segments and are therefore good materials for studying the evolution of the genome and are known as gene duplication fossils. Chromosome end repeats, single gene duplication and clustered homologous regions constitute the general structure of yeast genetic redundancy. Studies have shown that a group of genes in genetic redundancy tend to have the same or similar physiological functions, so that mutations in one or a few of them do not show discernable phenotypes. The functional study of yeast genes is very Adverse. Therefore, many yeast genetics believe that to understand the true nature of genetic redundancy and functional significance, as well as the development of experimental methods associated with this, is to reveal the major problems and central issues of the whole genome function of the yeast genome.