CA-125 卵巢癌抗原（鼠單克隆抗體）

CA-125 卵巢癌抗原（鼠單克隆抗體）

廣州健侖生物科技有限公司

CA125是1981年由Bast等從上皮性卵巢癌抗原檢測出可被單克隆抗體OC125結合的一種糖蛋白，來源于胚胎發(fā)育期體腔上皮，在正常卵巢組織中不存在，因此zui常見于上皮性卵巢腫瘤（漿液性腫瘤）患者的血清中，其診斷的敏感性較高，但特異性較差。黏液性卵巢腫瘤中不存在。80%的卵巢上皮性腫瘤患者血清CA125升高，但近半數(shù)的早期病例并不升高，故不單獨用于卵巢上皮性癌的早期診斷。90%患者血清CA125與病程進展有關，故多用于病情檢測和療效評估。95%的健康成年婦女CA125的水平≤40U/ml，若升高至正常值的2倍以上應引起重視。另外CA125也可見于結核性腹膜炎患者的血清檢查中，且CA125水平呈數(shù)十倍升高，在卵巢癌術前應明確排除結核性腹膜炎可能。

我司還提供其它進口或國產試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團菌、化妝品檢測、食品安全檢測等試劑盒以及日本生研細菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產品。

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【產品介紹】

細胞定位：細胞漿/細胞膜

克隆號：OC125

同型：IgG1/k

適用組織：石蠟/冰凍

陽性對照：卵巢癌/子宮內膜癌

抗原修復：熱修復（EDTA）

抗體孵育時間：30-60min

CA-125 卵巢癌抗原（鼠單克隆抗體）

抗原抗體反應性曲霉菌病
過敏體制者吸入大量含有曲霉孢子的塵埃，引起過敏性鼻炎、支氣管哮喘，支氣管炎或變性肺曲霉菌病。吸入后數(shù)小時出現(xiàn)喘息、咳嗽和咳痰，可伴發(fā)熱。大多數(shù)患者3—4天緩解，如再吸入又復發(fā)上述癥狀，痰中可檢出大量嗜酸性粒細胞和菌絲。培養(yǎng)見煙熏色曲霉菌生長，血嗜酸性粒細胞增多（>1.0×109/L），血清IgE>1000ng/ml。
全身性曲霉菌病
多見于原發(fā)性和繼發(fā)性免疫缺陷者。曲霉菌多由肺部病灶進入血循環(huán)，播散至全身多個臟器。白血病、惡性淋巴瘤、腫瘤、慢性肺部疾患、長期適用抗生素和皮質激素等，是發(fā)生本病的誘因。其臨床表現(xiàn)隨所侵犯的臟器而異，臨床上以發(fā)熱、全身中毒癥狀和栓塞zui常見。累及信內膜、心肌或心包，引起化膿、壞死和肉芽腫，中樞神經系統(tǒng)受累引起腦膜炎和腦膿腫。消化系統(tǒng)以及肝受累多見。
疾病病因
曲霉菌屬絲狀真菌，是一種常見的條件致病性真菌，引起人類疾病常見的有煙曲霉菌和黃曲霉菌。
曲霉菌廣布自然界，存在土壤、空氣、植物、野生或家禽動物及飛鳥的皮毛。也常見于農田、馬棚、牛欄、谷倉等處?？杉纳谡Ｈ说钠つw和上呼吸道，為條件致病菌。一般正常人對曲霉菌有一定的抵抗力，不引起疾病。曲霉菌病大多為繼發(fā)性，當機體抵抗力降低時，病原菌可經皮膚黏膜損傷處或吸入呼吸道，進而進入血液循環(huán)到其他組織或抗原抗體而致病。過敏體制者吸入曲霉菌孢子可觸發(fā)IgE介導的變化反應而支氣管痙攣。
病理生理
曲霉菌zui常侵犯支氣管和肺，可侵犯鼻竇、外耳道、眼和皮膚，或抗原抗體行播散至全身各抗原抗體。病變早期為彌漫性浸潤滲出性改變；晚期為壞死，化膿或肉芽腫形成。病灶內可找到大量菌絲。菌絲穿透血管可引起血管炎、血管周圍炎、血栓形成等，血栓形成又使組織缺血、壞死。

我司還提供其它進口或國產試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團菌、化妝品檢測、食品安全檢測等試劑盒以及日本生研細菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產品。

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

Antigen Antibody Reactivity Aspergillosis
People with allergies inhale large amounts of dust containing Aspergillus spores, causing allergic rhinitis, bronchial asthma, bronchitis, or degenerative lung aspergillosis. A few hours after inhaling wheezing, coughing and expectoration may be associated with fever. Most patients 3-4 days to ease, such as re-inhalation and relapse of the above symptoms, sputum can be found in a large number of eosinophils and hyphae. See culture of Aspergillus smithii, blood eosinophilia (> 1.0 × 109 / L) and serum IgE> 1000 ng / ml.
Systemic aspergillosis
More common in primary and secondary immune deficiency. Aspergillus into the blood circulation by the lung lesions, spread to multiple organs throughout the body. Leukemia, malignant lymphoma, cancer, chronic lung disease, long-term use of antibiotics and corticosteroids, is the cause of the disease. Its clinical manifestations vary with the organs of infringement, clinical fever, systemic symptoms and embolism most common. Endocardial involvement of the letter, myocardium or pericardium, causing purulent, necrotic and granulomatous, central nervous system involvement cause meningitis and brain abscess. Digestive system and liver involvement more common.
Etiology of the disease
Aspergillus filamentous fungus, is a common condition pathogenic fungi, caused by human diseases are common Aspergillus fumigatus and Aspergillus flavus.
Aspergillus Widely distributed in nature, there is the soil, air, plants, wild or poultry animals and birds fur. Also common in farmland, horse shed, bullpen, barns and other places. Can be parasitic on normal skin and upper respiratory tract, as a condition of pathogenic bacteria. Normal normal people have some resistance to Aspergillus, does not cause disease. Aspergillosis is mostly secondary, when the body resistance is reduced, the pathogen can be inhaled through the skin and mucosal injury or respiratory tract, and then into the blood circulation to other tissues or antigen-antibody and pathogenic. Allergic aspiration of aspergillus spores triggers IgE-mediated changes in response to bronchospasm.
Pathophysiology
Aspergillus most often violates the bronchi and lungs and can invade the sinuses, external auditory meatus, eyes and skin, or antigen-antibody lines spread to all body antigens. Early diffuse diffuse infiltration of exudative changes; advanced necrosis, suppuration or granuloma formation. A large number of mycelium can be found within the lesion. Hyphae penetrate the blood vessels can cause vasculitis, perivascular inflammation, thrombosis, thrombosis and tissue ischemia and necrosis.