細(xì)胞增殖指數(shù)（克隆號：MIB-1）

Ki67 細(xì)胞增殖指數(shù)（克隆號：MIB-1）

廣州健侖生物科技有限公司

Ki-67抗原是一種與細(xì)胞增殖特異相關(guān)的核抗原，主要用于研究細(xì)胞增殖活性。Ki-67在所有細(xì)胞周期活動(dòng)期（G1晚期、S、G2和M期）的增殖細(xì)胞中表達(dá)，但在靜止細(xì)胞中不表達(dá)。

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Ki67 細(xì)胞增殖指數(shù)（克隆號：MIB-1）

【產(chǎn)品介紹】

細(xì)胞定位：細(xì)胞漿

克隆號：SP6

同型：IgG1

適用組織：石蠟/冰凍

陽性對照：扁桃體/乳腺癌

抗原修復(fù)：熱修復(fù)（EDTA）

抗體孵育時(shí)間：30-60min

Ki67

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】     歐

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

UT西南醫(yī)學(xué)中心細(xì)胞生物學(xué)副主席Jerry W. Shay教授及其同事、細(xì)胞生物學(xué)和內(nèi)科醫(yī)學(xué)教授Woodring E. Wright發(fā)現(xiàn)，6-thio-2'-脫氧鳥苷(6-thio-2'-deoxyguanosine)能阻止培養(yǎng)物中癌細(xì)胞的生長，并減少小鼠體內(nèi)腫瘤的生長。
Harold C. Simmons 綜合癌癥中心副主任Shay博士說：“我們觀察到，用很低濃度的6-thiodG，就能有效地對抗一系列癌細(xì)胞系，并且減輕小鼠體內(nèi)的腫瘤負(fù)荷。”
相關(guān)研究結(jié)果發(fā)表在zui近的*學(xué)術(shù)期刊《Cancer Discovery》，本文共同資深作者是Shay和Wright博士。
6-thiodG通過靶定一種*的機(jī)制而發(fā)揮作用，這種機(jī)制被認(rèn)為可調(diào)節(jié)細(xì)胞的存活時(shí)間，是一種衰老時(shí)鐘。這種生物鐘被定義為一種DNA結(jié)構(gòu)，稱為端粒，其位于細(xì)胞染色體末端，可保護(hù)染色體不受傷害，每當(dāng)細(xì)胞分裂時(shí)它就會(huì)縮短。一旦端?？s短到臨界長度，細(xì)胞就不再分裂，并通過一個(gè)稱為細(xì)胞凋亡的過程死亡。

The Ki-67 antigen is a nuclear antigen that is specifically associated with cell proliferation and is used primarily to study cell proliferative activity. Ki-67 is expressed in proliferating cells in all cell cycle phases (late G1, S, G2 and M phases), but not in quiescent cells. Jerry W. Shay, vice president of cell biology at UT Southwestern Medical Center and his colleague Woodring E. Wright, professor of cellular and medical science, found that 6-thio-2'-deoxyguanosine ) Can prevent the growth of cancer cells in culture and reduce the growth of tumors in mice.
"We observed that with a very low concentration of 6-thiodG, we were able to effectively fight a series of cancer cell lines and reduce the tumor burden in mice," said Dr. Shay, associate director of the Harold C. Simmons Comprehensive Cancer Center.
Relevant research results published in the recent top international academic journals Cancer Discovery, co-senior author of this article are Dr. Shay and Wright.
6-thiodG works by targeting a unique mechanism that is thought to regulate cell survival and is an aging clock. This biological clock is defined as a DNA structure called a omere located at the end of a cell's chromosome that protects the chromosome from harm and shortens it whenever the cell divides. Once the omere has shortened to a critical length, the cells no longer divide and die through a process called apoptosis.