增殖細胞核抗原

PCNA 增殖細胞核抗原? 

廣州健侖生物科技有限公司

PCNA 是和細胞周期相關的36kD的核蛋白，是細胞DNA合成所必需的蛋白。此抗體可作為細胞增殖指數(shù)的主要參考依據(jù)，用于研究惡性腫瘤的細胞增殖和判斷其惡性度，對腫瘤的治療及預后的研究有一定的意義。

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PCNA 增殖細胞核抗原?? 

【產(chǎn)品介紹】

細胞定位：細胞核

克隆號：PC10

適用組織：石蠟/冰凍

陽性對照：扁桃體

抗原修復：熱修復（檸檬酸）

抗體孵育時間：30-60min

PCNA

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】     歐

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

有上皮腫瘤細胞核SIP1染色陽性的腫瘤更晚期。有更多的淋巴結(jié)轉(zhuǎn)移。內(nèi)皮細胞中表達SNAI1預示患者存活率降低，腫瘤大小增加。而基質(zhì)細胞TWIST表達與高復發(fā)風險有。
病人和醫(yī)生往往不知道手術切除癌變組織后是否很成功，直到手術幾個月后再進行掃描時才能知道?，F(xiàn)在，一種新的納米顆粒可以更早地顯示患者在手術后是否成功切除了全部癌變組織。
這種納米顆粒被稱為納米耀斑(nanoflares)。在實驗時，顆粒會依附于血液樣品中的每一個單獨的癌細胞上，然后會發(fā)光。通過激光的輔助可以檢測到癌細胞或?qū)ζ浞诸悺Ｒ驗橛泻芏嗖煌愋偷陌┘毎?，其中有一些癌細胞遠遠比其他的更加致命，通過使用這個技術可以檢測到這些更致命癌細胞并采集它們，因為這些細胞在采集之后還可以在培養(yǎng)皿中進行培養(yǎng)，用納米顆粒還可以在給病人真正治療前，更容易地測試一些潛在的治療方案。
研究人員表明，目前該納米顆?？蓹z測小鼠不同類型的抗原抗體癌細胞。他們還表明，納米顆粒在添加進人類血液后也能識別出抗原抗體癌細胞。他們下一步是確定該顆粒能否從患者體內(nèi)提取的血液樣本中發(fā)現(xiàn)癌細胞。

SIP1-positive tumors with epithelial tumor nuclei are more advanced. There are more lymph node metastases. The expression of SNAI1 in endothelial cells predicts a decrease in patient survival and an increase in tumor size. The expression of stromal cells TWIST is associated with a high risk of recurrence.
Patients and doctors often do not know whether successful surgical resection of cancerous tissue is successful until a few months after the surgery before scanning. Now, a new nanoparticle can show earlier whether the patient successfully resected all cancerous tissue after surgery.
This type of nanoparticle is called nanoflares. During the experiment, the particles attach to each individual cancer cell in the blood sample and then glow. Cancer cells can be detected or classified by the help of laser. Because there are many different types of cancer cells, some of which are far more lethal than others, these more deadly cancer cells can be detected and harvested using this technique because they can also be collected in a Petri dish For incubation, using nanoparticles also makes it easier to test some potential treatment options before actually treating the patient.
Researchers have shown that at present the nanoparticles can detect different types of antigen in mice antibody cancer cells. They also show that nanoparticles can also recognize antigen-presenting cancer cells when added to human blood. Their next step is to determine if the particle can find cancer cells in blood samples taken from the patient's body.