MSA肌肉特異性肌動蛋白（鼠單克隆抗體）Actin,Muscle Specific

廣州健侖生物科技有限公司

肌動蛋白是一種中等大小的蛋白質， 由375個氨基酸殘基組成， 并且是由一個大的、高度保守的基因編碼。 以兩種形式存在， 即單體和多聚體。單體的肌動蛋白是由一條多肽鏈構成的球形分子， 又稱球狀肌動蛋白(globular actin, G-actin),外形類似花生果。肌動蛋白的多聚體形成肌動蛋白絲， 稱為纖維狀肌動蛋白(fibros actin, F-actin)。在電子顯微鏡下， F-肌動蛋白呈雙股螺旋狀， 直徑為8nm, 螺旋間的距離為37nm。肌動蛋白是真核細胞中zui豐富的蛋白質。在肌細胞中， 肌動蛋白占總蛋白的10%, 即使在非肌細胞中， 肌動蛋白也占細胞總蛋白的1～5%。

MSA可以識別骨骼肌、心肌和平滑肌的α肌動蛋白和γ肌動蛋白，用以標記骨骼肌、心肌和平滑肌及其來源的腫瘤。非肌肉細胞如血管內皮細胞和結締組織不與之反應。因此，非肌源性腫瘤如上皮腫瘤、黑色素瘤、淋巴瘤等對于該抗體呈陰性表達。

我司還提供其它進口或國產試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團菌、化妝品檢測、食品安全檢測等試劑盒以及日本生研細菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產品。

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【產品介紹】

細胞定位：細胞漿

克隆號：HHF35

同型：IgG1/K

適用組織：石蠟/冰凍

陽性對照：闌尾

抗原修復：熱修復（EDTA）

抗體孵育時間：30-60min

MSA肌肉特異性肌動蛋白（鼠單克隆抗體）Actin,Muscle Specific

臨床表現
普通型起病一般緩慢，有腹部不適，大便稀薄，有時腹瀉，每日數次，有時亦可便秘。腹瀉時大便略有膿血痢疾樣。如病變發(fā)展，痢疾樣大便可增至每日10～15次或以上，伴有里急后重，腹痛加劇和腹脹。回盲腸、橫結腸，尤其是直腸部可有壓痛，有時象潰瘍病或闌尾炎。全身癥狀一般較輕微，同細菌性痢疾迥然不同。糞檢可有少量或多量滋養(yǎng)體，大便有抗原抗體腥臭。
阿米巴肝膿腫癥狀的出現，約在腸阿米巴數月、數年，甚至十數年之后，亦有從未患過腸阿米巴病的。起病大多緩漸，以長期不規(guī)則發(fā)熱與夜間盜汗等消耗性癥狀為主，在發(fā)病前一周至數年間可有類似痢疾樣發(fā)作史。實驗室檢查疾病早期白細胞總數有顯著增加，在15，000～35，000之間，中性粒細胞可超出80%。糞便內如能找到滋養(yǎng)體或包囊，對診斷有助。通過診斷性穿刺，如能抽出典型巧克力樣膿液并在其中找到夏一雷結晶及組織殘余，診斷即可確立，如再能檢得阿米巴滋養(yǎng)體，診斷更為確切。
并發(fā)癥
有腸內、腸外兩大類。腸外并發(fā)癥將在肝阿米巴病及其他少見腸外阿米巴病中敘述。以下系指阿米巴病的腸內并發(fā)癥。
1．腸穿孔：此系腸阿米巴病威脅生命zui大的并發(fā)癥。穿孔可因腸壁病變使腸腔內容物滲入腹腔釀成局限性或彌漫性腹膜炎或腹腔膿腫，亦偶因直腸鏡檢查時外傷性穿破而造成。彌漫性腹膜炎較多見，預后不良。腸壁深潰瘍大多引起慢性穿孔，部位多在盲腸、闌尾。外傷性穿孔多見于直腸。
2．腸出血深部潰瘍：可以侵蝕血管，引起大小不等的腸出血，大出血威脅生命，必須積極搶救并給予抗阿米巴藥物治療。
3．闌尾炎：阿米巴可侵襲闌尾，臨床上表現與一般闌尾炎相似的癥狀，偶可成為腸阿米巴病首先出現的癥狀，易發(fā)生穿孔。
4．阿米巴瘤：阿米巴潰瘍深入肌層，病變影響整個腸腔，產生大量肉芽組織，可形主能摸及的大腫塊，多位于盲腸，亦見于橫結腸、直腸及抗原抗體，極似腫瘤，不易與腸癌區(qū)別。偶可引起腸梗阻。
5．其他阿米巴痢疾反復發(fā)作后可引起潰瘍性結腸炎。有時出現腸套疊，大多位子盲腸結腸交界，可有劇痛與塊狀物摸及。結腸狹窄在慢性阿米巴痢疾后可出現，但較少見。
6、肝阿米巴?。菏侵溉芙M織內阿米巴通過門靜脈到達肝臟，引起肝細胞溶化壞死，成為膿腫，通常稱為阿米巴肝膿腫，為腸阿米巴病zui多見的并發(fā)癥，以長期發(fā)熱、自細胞增加、全身消耗及肝臟腫大與壓痛為其主要癥狀，并易于導致抗原抗體并發(fā)癥。約半數的阿米巴肝膿腫患者自一周至數年前曾有患類似阿米巴痢疾史。

我司還提供其它進口或國產試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團菌、化妝品檢測、食品安全檢測等試劑盒以及日本生研細菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產品。

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

Clinical manifestations
Common type of onset generally slow, abdominal discomfort, thin stools, sometimes diarrhea, several times a day, and sometimes also constipation. Diarrhea stool slightly when blood-like dysentery-like. Such as lesion development, dysentery-like stool can be increased to 10 to 15 times daily or more, with tenesmus, abdominal pain and bloating. Back to the cecum, transverse colon, especially the rectum may have tenderness, sometimes like ulcer disease or appendicitis. General symptoms are mild, very different from bacillary dysentery. Fecal semen may have small or large amount of trophozoites, stools have anti-stenosis antibodies.
Emergence of amoeblastic liver abscess symptoms, about a few months in the amoeba, a few years, or even a few years later, have never had intestinal amebiasis. Most of the onset gradually gradual, with long-term irregular fever and night sweats and other wasting symptoms mainly in the week before onset to several years may have similar dysentery-like episodes. In laboratory tests, the total number of leukocytes in the early stage of the disease is significantly increased. Neutrophils may exceed 80% between 15,000 and 35,000. If found within the feces nourishment or cysts, the diagnosis will help. Through diagnostic puncture, such as the typical chocolate-like pus can be extracted and found in a summer of crystal and tissue remnants of the mine, the diagnosis can be established, such as re-seizure of amebic trophozoites, the diagnosis is more specific.
complication
There are two types of enteral and parenteral. Extraintestinal complications will be described in hepatomitamiasis and other rare extra-intestinal amoebiasis. The following refers to the enteral complications of amoebiasis.
1. Bowel Perforation: This enalapril is a life-threatening complication. Perforation of the bowel wall lesions can make the contents of the intestine into the abdominal cavity caused by localized or diffuse peritonitis or abdominal abscess, and occasionally because of traumatic penetrance of colonoscopy caused by puncture. Diffuse peritonitis more common, poor prognosis. Mucosal deep ulcers mostly cause chronic perforation, the site more in the cecum, appendix. Traumatic perforation more common in the rectum.
2. Intestinal ulcer deep ulcer: can erode the blood vessels, causing intestinal bleeding of varying sizes, bleeding-threatening life, must be actively rescued and given anti-amoeba drug treatment.
3. Appendicitis: Amoeba can affect the appendix, the clinical manifestations of symptoms similar to the general appendicitis, even can be the first symptoms of intestinal amoebiasis, prone to perforation.
4. Amoeba tumor: amoeba ulcer deep muscular layer, the lesion affects the entire intestine, resulting in a large number of granulation tissue, the main form can touch the large mass, mostly in the cecum, also found in the transverse colon, rectum and antigen antibodies, , Not easy to distinguish with intestinal cancer. Even can cause intestinal obstruction.
5. Repeated attacks of other amoebic dysentery can cause ulcerative colitis. Sometimes intussusception, most of the junction of the cecum colon, there may be pain and block touch. Colon stenosis can occur after chronic amebic dysentery but is less common.
6, hepatic amebiasis: refers to the dissolved tissue of amoeba through the portal vein to reach the liver, causing liver cell necrosis, become abscess, commonly known as amoebiasis abscess, is the most common complication of enteramoma , To long-term fever, increased from the cell, the whole body consumption and enlargement and tenderness of the liver as its main symptoms, and easily lead to antigen-antibody complications. About half of patients with amoebic liver abscess have had a history similar to that of amoebic dysentery from one week to several years ago.