鞘磷脂、腦苷脂以及神經(jīng)節(jié)苷脂系列同位素標(biāo)記簡(jiǎn)介

鞘磷脂、腦苷脂以及神經(jīng)節(jié)苷脂系列同位素標(biāo)記簡(jiǎn)介

    鞘脂是一類(lèi)含有鞘氨醇骨架的兩性脂，是僅次于磷脂的第二大類(lèi)膜脂。鞘脂一端連接著一個(gè)長(zhǎng)鏈的脂肪酸，另一端為一個(gè)極性的醇。鞘脂正常代謝的維持不僅是細(xì)胞生存的關(guān)鍵，也對(duì)包括抗病免疫調(diào)控、植物育性等在內(nèi)的發(fā)育過(guò)程，有著十分重要的作用。絲氨酸棕櫚酰轉(zhuǎn)移酶（Serine palmitoyltransferase, SPT）是催化鞘脂合成的步，同時(shí)也是關(guān)鍵的限速步驟。在人和酵母中，類(lèi)黏膜蛋白（Orosomucoid, ORM）通過(guò)負(fù)調(diào)控SPT酶來(lái)維持細(xì)胞內(nèi)的鞘脂穩(wěn)態(tài)。穩(wěn)定的同位素標(biāo)準(zhǔn)可以很容易地檢測(cè)到質(zhì)譜，同時(shí)相比天然鞘脂顯示出幾乎相同的物理性質(zhì),這對(duì)于確保分析物和內(nèi)部標(biāo)準(zhǔn)物之間具有相似的提取特性和信號(hào)響應(yīng)非常重要。
    鞘脂包括鞘磷脂、腦苷脂以及神經(jīng)節(jié)苷脂，一般存在于植物和動(dòng)物膜內(nèi)，尤其是在中樞神經(jīng)系統(tǒng)的組織內(nèi)含量豐富。又稱(chēng)鞘磷脂、鞘氨醇磷脂或神經(jīng)磷脂·由鞘氨醇、脂肪酸與磷酰膽堿組成的分子，它是鞘磷脂類(lèi)的典型代表，在高等動(dòng)物的組織中含量極為豐富。鞘脂作為信號(hào)分子在植物生長(zhǎng)和脅迫過(guò)程中扮演著重要的角色。

     With the availability of stable isotope standards and the incorporation of soft ionization techniques in mass spectrometry the detection of very small amounts of sphingolipids can be accomplished. The two major approaches of sphingolipidomic studies are the liquid chromatography-mass spectrometry based methods and the shotgun lipidomics approach.These techniques require the use of internal standards for each class of sphingolipid expected to be found in a sample. Stable isotope standards can be easily detected by mass spectrometry while demonstrating nearly identical physical properties as compared to natural sphingolipids. This is very important to ensure similar extraction properties and signal response between the analytes and the internal standards.

D-erythro-Sphingosine, D9     1 mg

Synonym:15,15,16,16,17,17,18,18,18-D9-2-Amino-octadec-4-ene-1,3-diol;

N-omega-CD3-Octadecanoyl-D-erythro-sphingosine    1 mg

N-(32-Linoleoyloxy-dotriacontanoyl)-sphingosine-D9  1 mg

N-omega-CD3-Octadecanoyl-D-erythro-dihydrosphingosine  1 mg

N-1-13C-Hexadecanoyl-D-erythro-sphingosylphosphorylcholine   1mg

N-Octadecanoyl-D3-D-erythro-sphingosine-1-phosphate, deuterated   1 mg $

N-Octadecanoyl-D35-psychosine, (perdeuterated, C18:0 fatty acid)   5 mg

N-omega-CD3-Hexadecanoyl-glucopsychosine   1 mg

N-omega-CD3-Octadecanoyl-sulfatide   1 mg

N-omega-CD3-Hexadecanoyl-lactosylceramide   1 mg

N-omega-CD3-Octadecanoyl-ceramide trihexoside   500 µg

N-omega-CD3-Octadecanoyl monosialoganglioside GM1 (NH4+ salt)   500 µg

N-omega-CD3-Octadecanoyl monosialoganglioside GM2 (NH4+ salt)   250 ug

N-omega-CD3-Octadecanoyl monosialoganglioside GM3 (NH4+ salt)  250 ug

N-omega-CD3-Octadecanoyl disialoganglioside GD3   500 µg

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