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世聯(lián)博研(北京)科技有限公司>技術(shù)文章>BIOMOMENTUM MACH-1 力學(xué)試驗機--自動壓痕映射

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BIOMOMENTUM MACH-1 力學(xué)試驗機--自動壓痕映射

閱讀:547          發(fā)布時間:2021-3-15
Automated Indentation Mapping of Vocal Fold Structure and Cover Properties across Species
跨物種的聲帶折疊結(jié)構(gòu)和覆蓋特性的自動壓痕映射
Gregory R. Dion, MD, Jean-Francois Lavoie, PhD, Paulo Coelho, DDS, PhD, Milan R. Amin, MD, Ryan C. Branski, PhD
Laryngoscope. 2018 Nov 8. doi: 10.1002/lary.27341
Objectives/Hypothesis: Various animal models have been employed to investigate vocal fold (VF) and phonatory function. However, biomechanical testing techniques to characterize vocal fold structural properties vary and have not compared critical properties across species. We adapted a nondestructive, automated indentation mapping technique to simultaneously quantify VF structural properties (VF cover layer and intact VF) in commonly used species based on the hypothesis that VF biomechanical properties are largely preserved across species.

Study Design: Ex vivo animal model.


Methods: Canine, leporine, and swine larynges (n = 4 each) were sagittally bisected, measured, and subjected to normal indentation mapping (indentation at 0.3 mm; 1.2 mm/s) with a 2-mm spherical indenter to quantify normal force along the VF cover layer, structural stiffness, and displacement at 0.8 mN; two-dimensional maps of the free VF edge through the conus elasticus were created for these characterizations.

方法:將 犬,豬膽堿和豬喉(每組n = 4)矢狀平分,測量,并用BIOMOMENTUM MACH-1 力學(xué)試驗機  2 mm球形壓頭進行法向壓痕測繪(壓痕為0.3 mm; 1.2 mm / s)以量化沿法向力VF覆蓋層,結(jié)構(gòu)剛度和在0.8 mN時的位移;為了描述這些特征,創(chuàng)建了穿過圓錐彈性體的自由VF邊緣的二維圖。


Results: Structural stiffness was 7.79 gf/mm (0.15–74.55) for leporine, 2.48 gf/mm (0.20–41.75) for canine, and 1.45 gf (0.56–4.56) for swine. For each species, the lowest values were along the free VF edge (mean ± standard deviation; leporine: 0.40 ± 0.21 gf/mm, canine: 1.14 ± 0.49 gf/mm, swine: 0.89 ± 0.28 gf/mm). Similar results were obtained for the cover layer normal force at 0.3 mm. On the free VF edge, mean (standard deviation) displacement at 0.08 gf was 0.14 mm (0.05) in leporine, 0.11 mm (0.03) in canine, and 0.10 mm (0.02) in swine.

Conclusions: Automated indentation mapping yielded reproducible biomechanical property measurement of the VF cover and intact VF. Divergent VF structural properties across canine, swine, and leporine species were observed.

Key Words: Larynx, vocal fold, mechanical testing, indentation, voice, structural stiffness.
 

該多軸多材料功能機械力特性測試儀是能集成壓縮、張力、剪切、摩擦、穿刺、扭轉(zhuǎn)和壓痕、活性組織電位分布測試的一體化測試與培養(yǎng)裝置。能對生物組織、聚合物、凝膠、生物材料、膠囊、粘合劑和食品進行精密可靠的機械刺
激和表征。允許表征的機械性能包括剛度、強度、模量、粘彈性、塑性、硬度、附著力、腫脹和松弛 位移控制運動。
 

相比于傳統(tǒng)的大型力學(xué)測試系統(tǒng),該微觀力學(xué)測試系統(tǒng)總體較小,可以實現(xiàn)桌面化的操作流程,操作過程簡便。該系統(tǒng)測試方法面,是多樣化的材料力學(xué)表征工具,是科學(xué)家、工程師和其他各領(lǐng)域用戶的佳選擇。在動態(tài)力學(xué)分析、薄膜、復(fù)合物、聚合物、生物產(chǎn)品、醫(yī)學(xué)鑒定和水凝膠等領(lǐng)域都有廣泛應(yīng)用。
 

材料力學(xué)性能是指材料在不同環(huán)境(溫度、介質(zhì)、濕度)下,承受各種外加載荷(拉伸、壓縮、彎曲、扭轉(zhuǎn)、沖擊、交變應(yīng)力等)時所表現(xiàn)出的力學(xué)特征。


測試意義及適用范圍:

 


系統(tǒng)亮點:

可在標(biāo)準(zhǔn)的培養(yǎng)皿中進行力學(xué)刺激實驗;

可滿足作為理想的實驗和教學(xué)工具;

大范圍高精度多軸測試:可測量動態(tài)、靜態(tài)和各種波形的壓縮、張力、剪切和扭矩

用戶友好的軟件用于的數(shù)據(jù)采集和簡易的分析, 采集的數(shù)據(jù)可導(dǎo)入三方軟件進一步分析。

皮膚彈性測試---軟組織彈性測試;

纖維材料的彈性--材料彈性測試;

縫合傷口材料--材料彈性、壓力應(yīng)變測試;

傷口愈合評定--材料彈性、壓力應(yīng)變測試;

細(xì)胞組織培養(yǎng)物雙向模擬--材料壓力、剪切應(yīng)變測試;

藻酸鹽微球力學(xué)評估--材料彈性、壓力、剪切應(yīng)變測試; 

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