GLP-1R/CRE Luciferase Reporter HEK293 Cell Line 返回列表頁(yè)

GLP-1R/CRE Luciferase Reporter HEK293 Cell Line is an engineered HEK293 cell line expressing firefly luciferase under the control of cAMP response element (CRE), and human GLP-1R (Glucagon-like peptide 1 receptor; accession number BC113493). Activation of GLP-1R in these cells can be monitored by measuring luciferase activity.

The functionality of GLP-1R/CRE Luciferase Reporter HEK293 Cell Line was validated in dose-response assays using the peptide agonists Glucagon-like peptide 1 (7-37), Exendin-4, Lixisenatide, GLP-1 moiety from dulaglutide, Semaglutide, Tirzepatide and Retatrutide. This cell line has also been validated in a dose-response assay using a small molecule agonist, Danuglipron. GLP-1R/CRE Luciferase Reporter HEK293 Cell Line responds to agonists by inducing luciferase activity in a dose-dependent manner.

Figure 1. Illustration of mechanism of action in the GLP-1R/CRE Luciferase Reporter HEK293 Cell Line.

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