文獻名： Sodium carboxymethyl cellulose modulates the stability of cinnamaldehyde-loaded liposomes at high ionic strength

 

作者： Xuejiao Wang^a; Li Liu^a; Shuqin Xia^a,b; Bertrand Muhoza^a; Jibao Cai^b; Xiaoming Zhang^a; Emmanuel Duhoranimana^a; Jiakun Su^b

^aState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Collaborative Innovation Center of Food Safety and Quality Control, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu, 214122, People's Republic of China

^bCenter of R&D, China Tobacco Jiangxi Industrial Co., Ltd., Nanchang, 330096, People's Republic of China

 

摘要：In present study, three kinds of sodium carboxymethyl cellulose (CMCNa) were used to modulate the stability of cinnamaldehyde-loaded liposomes at high ionic strength (0.66?mol/L). The effects of different types and concentrations of CMCNa on the physical properties of liposomes were characterized by rheological properties, appearance, distribution, microstructure, particle size and dispersion. Rheology measurements showed that CMCNa endowed viscoelasticity to liposomes. The molecular mass (Mw) and concentration of CMCNa were positively correlated to liposome stability. CMCNa with Mw 1,185,955 was the most effective for liposomes stability at concentrations of 0.8% and 1.0% (w/v). Transmission electron microscope (TEM) results showed that CMCNa-П formed an associated layer around liposomes. Steric hindrance between particles was attributed to the improvement of stability of liposomes. Dispersion analysis demonstrated 0.8% and 1.0% CMCNa-П had the better stability. These results may contribute to the development of stable liposomes with potential applications for bioactive molecules encapsulation and delivery.