作者： Xin Tana, Pu Zhangb, Cuiying Yea, Yuanhong Mina, Qianwen Lia, Yi Wanga

a

Engineering Research Center for Biotechnology of Active Substances, Ministry of Education, Chongqing Key Laboratory of Green Synthesis and Applications, College of Chemistry, Chongqing Normal University, Chongqing, 401331, China

b

Chongqing Key Research Laboratory for Drug Metabolism, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China

 

摘要：Development of new methods for dopamine (DA) assay has attracted continuous attention because it serves a vital role in clinical treatment of neurological diseases such as depression, schizophrenia, and Parkinson's disease. Herein, we design a carbon dots (CDs)-MnO2 nanosheets platform for rapid and sensitive detection of DA in pharmaceutical products. The photoluminescence of CDs can be quenched by MnO2 nanosheets via inner filter effect (IFE) because the absorption of MnO2 nanosheets fully covered the excitation and emission bands of CDs. However, DA can transform MnO2 nanosheets into Mn2+ ions, resulting in the elimination of the IFE and recovery of the photoluminescent signal. This sensing platform shows a selective and sensitive response to DA in the range of 1–30 μM, with a detection limit of 100 nM. The presented IFE-based strategy gives a new insight on development of label-free, selective and sensitive optical methods for drug assay.