作者： Yumiao Zhang,^ab  Hao Hong,^c  Boyang Sun,^ab  Kevin Carter,^a  Yiru Qin,^a  Wei Wei,^d  Depeng Wang,^a  Mansik Jeon,^e  Jumin Geng,^a  Robert J. Nickles,^f  Guanying Chen,^dg  Paras N. Prasad,^d  Chulhong Kim,^h  Jun Xia,^a  Weibo Cai^f  and  Jonathan F. Lovell^ab

^aDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, USA

^bDepartment of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, USA

^cCenter for Molecular Imaging, University of Michigan, Ann Arbor, USA

^dInstitute for Lasers, Photonics, and Biophotonics and Department of Chemistry, University at Buffalo, State University of New York, Buffalo, USA

^eSchool of Electronics Engineering, College of IT Engineering, Kyungpook National University, Korea

^fDepartment of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, USA

^gSchool of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, People's Republic of China

^hCreative IT Engineering, Pohang University of Science and Technology, Korea

 

摘要：Surfactant-stripped, nanoformulated naphthalocyanines (nanonaps) can be formed with Pluronic F127 and low temperature membrane processing, resulting in dispersed frozen micelles with extreme contrast in the near infrared region. Here, we demonstrate that nanonaps can be used for multifunctional cancer theranostics. This includes lymphatic mapping and whole tumor photoacoustic imaging following intradermal or intravenous injection in rodents. Without further modification, pre-formed nanonaps were used for positron emission tomography and passively accumulated in subcutaneous murine tumors. Because the nanonaps used absorb light beyond the visible range, a topical upconversion skin cream was developed for anti-tumor photothermal therapy with laser placement that can be guided by the naked eye.