UbiQ-126 熒光探針泛素Ub-Rh110MP
參考價(jià) | ¥6050.00 |
- 公司名稱 靶點(diǎn)科技(北京)有限公司
- 品牌UbiQBio
- 型號UbiQ-126
- 所在地北京市
- 廠商性質(zhì)代理商
- 更新時間2025/1/19 9:45:01
- 訪問次數(shù) 42
50ug | 6050.00元 | 99 件可售 |
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供貨周期 | 兩周 | 規(guī)格 | 50ug |
---|---|---|---|
貨號 | UbiQ-126 | 主要用途 | Ub-Rh110MP(UbiQ-126)是脫泛素酶(DUBs)的淬滅熒光底物。 |
中文介紹:
UbiqBio熒光探針泛素Ub-Rh110MP:Ub-Rh110MP(UbiQ-126)是脫泛素酶(DUBs)的淬滅熒光底物。泛素的Gly76和羅丹明110部分之間的酰胺鍵的斷裂釋放出高度熒光的Rh110嗎啉羰基,其熒光強(qiáng)度高于Ub-Rh110Gly的經(jīng)典Rh110Gly熒光團(tuán)(UbiQ-002)。UbiQ-126是通過全化學(xué)合成制備的。
英文介紹:
UbiqBio熒光探針泛素Ub-Rh110MP:Ub-Rh110MP (UbiQ-126) is a quenched, fluorescent substrate for deubiquitylases (DUBs). Cleavage of the amide bond between Gly76 of ubiquitin and the Rhodamine110 moiety releases the highly fluorescent Rh110-morpholinecarbonyl which exhibits a higher fluorescence intensity than the classical Rh110Gly fluorophore of Ub-Rh110Gly (UbiQ-002). UbiQ-126 is prepared by total chemical synthesis.
產(chǎn)品被引文獻(xiàn):
1.Hassiepin, U., et al. A sensitive fluorescence intensity assay for deubiquitinating proteases using ubiquitin-rhodamine 110-glycine as substrate. Anal. Biochem. 371, 201-207 (2007). ncbi.nlm.nih.gov/pubmed/17869210
2.El Oualid, F., et al. Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin. Angewandte Chemie Int. Ed. 49, 10149-10153 (2010). ncbi.nlm.nih.gov/pubmed/21117055
3.Lavis, L.D., et al. Fluorogenic label for biomolecular imaging. ACS Chem. Biol. 1, 252-260 (2006). ncbi.nlm.nih.gov/pubmed/17163679
4.Terentyeva, T.G., et al. Morpholinecarbonyl-Rhodamine 110 based substrates for the determination of protease activity with accurate kinetic parameters. Bioconj. Chem. 22, 1932-1938 (2011). ncbi.nlm.nih.gov/pubmed/21905728