B細胞活化因子受體抗體 返回列表頁

英文名稱 BAFFR
中文名稱 B細胞活化因子受體抗體
別    名 B Cell Activating Factor Receptor; B-cell-activating factor receptor; BAFF R; BAFF receptor; BAFF-R; BAFFR; BLyS receptor 3; BlySR3; BR 3; BR3; BROMIX; CD 268; CD268; CD268 antigen; CVID4; MGC138235; OTTHUMP00000028746; Prolixin; TNFRSF 13C; TNFRSF13C; TR13C_HUMAN; Tumor Necrosis Factor Receptor Subunit Member 13C; Tumor necrosis factor receptor superfamily member 13C.
B細胞活化因子受體抗體   
說 明 書 0.2ml  
研究領域 細胞生物  信號轉(zhuǎn)導  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 19kDa
細胞定位 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human BAFFR
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq].

Function:
B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.

Subcellular Location:
Membrane; Single-pass type III membrane protein (Probable).

Tissue Specificity:
Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.

DISEASE:
Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.

Similarity:
Contains 1 TNFR-Cys repeat.

Gene ID:
115650

Database links:

Entrez Gene: 115650 Human

Entrez Gene: 72049 Mouse

Entrez Gene: 500910 Rat

Omim: 606269 Human

SwissProt: Q96RJ3 Human

SwissProt: Q9D8D0 Mouse

Unigene: 344088 Human

Unigene: 240047 Mousexy-2734R Bcl-6/5原癌基因Bcl-6抗體
xy-3011R phospho-Bcl 10 (Ser218)磷酸化Bcl-10抗體
xy-3012R phospho-Bim(Ser87)磷酸化細胞死亡調(diào)解子抗體
xy-3013R phospho-B-Raf (Ser365)磷酸化B-Raf抗體
xy-3014R Phospho-BRCA1 (Ser1524)磷酸化乳腺癌易感基因1抗體
xy-3750R BMAL1芳香烴受體核轉(zhuǎn)錄蛋白樣1抗體
xy-6888R BRCC3乳腺癌易感基因復合物亞基蛋白3抗體
xy-12418R BAMBI腫瘤轉(zhuǎn)移抑制蛋白BAMBI抗體
xy-12393R BCL9B淋巴細胞淋巴瘤因子9抗體
xy-12868R Biliverdin Reductase膽綠素還原酶抗體
xy-12869R BIVMBIVM蛋白抗體
xy-12870R Blood Group Lewis a血型Lewis A抗原抗體
xy-12871R Blood Group Lewis b粘蛋白/巖藻糖基轉(zhuǎn)移酶3抗體
xy-12872R BLMBloom綜合征相關蛋白抗體
xy-12873R BMP8b骨形態(tài)發(fā)生蛋白8b抗體
xy-12874R phospho-BMX (Tyr566)磷酸化非受體性蛋白酪氨酸激酶ETK抗體
xy-12875R phospho-BNIP3 (Ser95)磷酸化促凋亡調(diào)節(jié)蛋白BNIP3抗體
xy-12876R BOB1B淋巴細胞特異性激活OCT結合蛋白1抗體
xy-12877R BOP1核糖體合成蛋白BOP1抗體
xy-12878R BORA調(diào)節(jié)中心體分離早期相關激酶BORA抗體
xy-12879R Borrelia burgdorferi萊姆病螺旋體抗體
xy-12880R BOULE精子成熟相關蛋白BOULE抗體
xy-12881R BPOZ伸長因子結合蛋白抗體
xy-12882R BPY2睪丸特異性堿性蛋白Y2抗體
xy-12883R BRAF35乳腺癌易感基因2相關蛋白抗體
xy-12884R Phospho-BRCA1(Ser1280)磷酸化乳腺癌易感基因1抗體
xy-12885R Phospho-BRCA1 (Ser1387)磷酸化乳腺癌易感基因1抗體
xy-12886R Phospho-E Cadherin (Ser838 + Ser840)磷酸化上皮鈣粘附分子抗體
xy-12887R Phospho-BRCA1 (Ser1466)磷酸化乳腺癌易感基因1抗體