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MUC1抗體

抗原
Mucin 1, Cell Surface Associated (MUC1)
別名 CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM, Muc-1
適用
其他選擇 Human, Murine, Rat ((Rattus))
Human(501),Murine (57),Rat ((Rattus)) (33),Dog (Canine) (15),Bovine (8),Rabbit (4),Pig (Porcine) (3),Gibbon (1)
宿主
其他選擇 Rabbit
Mouse(303),Rabbit (204),Hamster (5),Chicken (4)
克隆類型
多克隆
標記
其他選擇 非結(jié)合性
Biotin(13),FITC (13),HRP (8),PE (5),APC (4),Alkaline Phosphatase (AP) (4),Alexa Fluor 350 (3),Alexa Fluor 488 (3),Alexa Fluor 555 (3),Alexa Fluor 647 (3),Cy3 (3),Cy5 (3),Cy5.5 (3),Cy7 (3),His tag (1),His tag,GST tag (1),Magnetic Particles (1),Sepharose (1)
應用范圍
其他選擇 Immunohistochemistry (Frozen Sections) (IHC (fro)), Dot Blot (DB), Enzyme Immunoassay (EIA), Western Blotting (WB)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))(234),ELISA (216),Western Blotting (WB) (173),Immunohistochemistry (Frozen Sections) (IHC (fro)) (145),Immunohistochemistry (IHC) (145),Immunofluorescence (IF) (108),Flow Cytometry (FACS) (58),Immunocytochemistry (ICC) (50),Immunoprecipitation (IP) (36),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (31),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (30),Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (22),Dot Blot (DB) (16),Enzyme Immunoassay (EIA) (15),Immunoelectron Microscopy (IEM) (11),Protein Assay (PrA) (5),Immunohistochemistry (Acetone-fixed) (IHC (af)) (4),Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (4)
[Pubmed] 6 references available
規(guī)格 0.1 mg
發(fā)貨至 中國 (更改)
發(fā)貨時間 29至35個工作日

MUC1抗體

產(chǎn)品細節(jié)

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產(chǎn)品細節(jié)

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免疫原 Synthetic peptide representing a 20 amino acid repeat sequence from mucin 1
序列 VTS APD TRP APG STA PPA HG
特異性 This antibody detects Mucin-1 (MUC1). It recognizes the mucin core protein, it is expected that it will recognize only the core protein when it is exposed due to under glyclosylation as seen in various carcinomas.
交叉反應 （詳細） Species reactivity (tested):Human, mouse, rat
純化方法 Affinity chromatography

目標詳細情況

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目標詳細情況

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別名 CD227 / Mucin-1 / MUC1
背景 Mucin 1 (Muc1) is a large transmembrane glycoprotein that is overexpressed by a majority of carcinomas. High expression of MUC1 is associated with aggressive tumors, and MUC1 antigen is used as a marker to monitor disease progression in breast cancer patients. Mucin is a mucopolysaccharidic matrix, its expression is widely varied during cell differentitiaon and inflammation. The extent of Glycosylation determines essential biological functions of epithelial mucins in conditions of health and disease. The mucin MUC1 is a candidate for use in specific immunotherapy against breast cancer. Mucin also protects the covering of gut epithelium where it is protected from proteolytic digestion by extensive glycosylation on the mucin molecule (1). The quantity and quality of mucins are also affected in inflammatory bowel disease (IBD) both because of a reduction in the number of goblet cells and a decrease in the number of sugar residues per oligosaccharide side chain (2). There are several mucin phenotypes examined in the gut (mucin 1-mucin 6), the expression of these mucin in various type of minute well-differentiated type adenocarcinoma has been examined for diagnostic purposes (3). The mucin knockout mice showed significant decrease in cholesterol uptake with no effect on fatty acif absorption (4). In breast cancer, overexpression of MUC1 suggest to contributes to cancer progression and metastasis. It has been shown that naturally occurring cancer preventative, indole-3-carbinol (I3C), inhibits the expression of MUC1 in breast cancer estrogen responsive and non-responsive cells (5). Unlike normal tissue where MUC exists as heavily glycosylated form, the disease- or tumor-associated MUC molecules are underglycosylated. Such underglycosylation of the core protein in cancer tissues exposes new epitopes on the cell surface that are unique to cancer tissues (6). Mucins are large glycoproteins characterized by mucin domains that show little sequence conservation and that are rich in the amino acids Ser, Thr and Pro. The sequentially-repeating nature of the core protein 20 a.a. polypeptide chain on the surface of malignant cells makes it a potential target for immunotherapy.Synonyms: Breast carcinoma-associated antigen DF3, CA 15-3, Carcinoma-associated mucin, DF3, EMA, Episialin, H23AG, MUC-1, PEMT, PUM, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin
基因ID 4582
NCBI Accession NP_001018016
UniProt P15941
研究領(lǐng)域 CD Antigens, Surface Receptors of Immune Cells

使用細節(jié)

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應用備注 Immunohistochemistry on frozen sections: 1: 200. Western blot. ELISA: 1: 10,000. Dot blot: 1: 10,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 For Research Use only

貯存及處理

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貯存及處理

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濃度 0.5 - 0.75 mg/mL
緩沖液 Stabilization buffer with preservatives
注意事項 Avoid repeated freezing and thawing.
儲存條件 -20 °C
儲存方法 Store (in aliquots) at -20 °C.

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