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STAT3抗體

抗原
Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3)
別名 1110034C02Rik, AW109958, Aprf, APRF, HIES, Xstat3, aprf, hies, stat3, wu:fc15d02, wu:fl59g06, z-Stat3
抗原表位
其他選擇 N-Term
pTyr705(75),pSer727 (63),C-Term (47),Ser727 (22),N-Term (12),Tyr705 (12),Internal Region (10),AA 50-240 (9),AA 673-699 (9),AA 711-743 (8),pTyr708 (7),AA 725-729 (5),AA 1-175 (3),AA 335-546 (3),AA 4-31 (3),AA 703-707 (3),AA 154-175 (2),AA 563-670 (2),AA 683-709 (2),Middle Region (2),Tyr708 (2),AA 1-170 (1),AA 1-350 (1),AA 1-769 (1),AA 1-770 (1),AA 135-279 (1),AA 346-552 (1),AA 51-278 (1),AA 529-747 (1),AA 576-678 (1),AA 656-705 (1),AA 656-768 (1),AA 670-769 (1),AA 670-770 (1),AA 672-721 (1),AA 675-725 (1),AA 688-722 (1),AA 701-710 (1),AA 703-714 (1),AA 708-770 (1),AA 720-732 (1),AA 720-770 (1),AA 722-732 (1),Asp733 (1),Isoform 1 (1),Pro699 (1),Ser691 (1),Ser705 (1),Ser721 (1),Thr721 (1),Transcript Variant 3 (1),Tyr1222 (1),Tyr1229 (1),Tyr694 (1),non-phosphorylated (1),pThr3 (1),pTyr68 (1),pTyr727 (1),phosphorylated (1),phosphospecific (1)
適用
其他選擇 Murine, Rat ((Rattus)), Xenopus laevis, Pig (Porcine), Bovine, Dog (Canine), Zebrafish (Danio rerio), Human, Chicken
Human(386),Murine (194),Rat ((Rattus)) (162),Dog (Canine) (46),Bovine (44),Pig (Porcine) (39),Chicken (38),Guinea Pig (36),Zebrafish (15),Monkey (8),Rat (Meriones) (2),Hamster (1),Xenopus laevis (1),Zebrafish (Danio rerio) (1)
宿主
其他選擇 Rabbit
Rabbit(367),Mouse (54),Goat (9),Sheep (3),Chicken (1)
克隆類(lèi)型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
Biotin(16),FITC (11),HRP (8),PE (6),APC (5),Alkaline Phosphatase (AP) (5),Alexa Fluor 647 (4),Alexa Fluor 350 (3),Alexa Fluor 488 (3),Alexa Fluor 555 (3),Cy3 (3),Cy5 (3),Cy5.5 (3),Cy7 (3),CF (1),Magnetic Particles (1),Sepharose (1)
應(yīng)用范圍
其他選擇 Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)
Western Blotting (WB)(375),Immunohistochemistry (IHC) (164),ELISA (155),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (88),Immunoprecipitation (IP) (71),Immunofluorescence (IF) (60),Immunocytochemistry (ICC) (49),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (30),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (22),Immunohistochemistry (Frozen Sections) (IHC (fro)) (18),Enzyme Immunoassay (EIA) (11),Flow Cytometry (FACS) (11),Dot Blot (DB) (5),Gel Shift (GS) (3),Proximity Ligation Assay (PLA) (3),Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2),Immunoassay (IA) (1)
[Pubmed] 1 reference available
規(guī)格 50 μg
發(fā)貨至 中國(guó) (更改)
發(fā)貨時(shí)間 9至12個(gè)工作日

STAT3抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

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免疫原 Synthetic peptide directed towards the N terminal of human STAT3
序列 AQWNQLLD TRYLEQLHQL YSDSFPMELR QFLAPWIESQ DWAYAASKES
預(yù)測(cè)反應(yīng) Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Zebrafish : 70 %
產(chǎn)品特性 This is a rabbit polyclonal antibody against STAT3. It was validated on Western Blot using a cell lysate as a positive control.
純化方法 Affinity Purified

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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別名 STAT3
背景 STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. It mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
分子量 88 kDa
基因ID 6774
NCBI Accession NP_003141, NM_003150
UniProt B5BTZ6
研究領(lǐng)域 Embryogenesis, Embryonic stem cells, Transcription Factors, Signaling, Receptors, Inflammation

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使用細(xì)節(jié)

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應(yīng)用備注 Optimal working dilutions should be determined experimentally by the investigator.
說(shuō)明

Antigen size: 769 AA

限制 For Research Use only

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貯存及處理

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狀態(tài) Lyophilized
溶解方式 Add 50 µL of distilled water.
濃度 1 mg/mL
緩沖液 PBS buffer with 2 % sucrose
注意事項(xiàng) Avoid repeated freeze-thaw cycles.
儲(chǔ)存條件 -20 °C
儲(chǔ)存方法 For longer periods of storage, store at -20 °C

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