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GNS抗體

抗原
Glucosamine (N-Acetyl)-6-Sulfatase (GNS)
別名 NV14559, N-acetylglucosamine-6-sulfatase, zgc:114066, G6S, 2610016K11Rik, AU042285, C87209, N28088, gns, wu:fi20h10, zgc:55370
抗原表位
其他選擇 AA 1-552
AA 1-552(9),C-Term (6),Internal Region (3),AA 283-313 (2),Middle Region (2),AA 243-490 (1),AA 291-320 (1),AA 37-552 (1),AA 66-331 (1),Center (1),Ser298 (1)
適用
其他選擇 Human
Human(43),Rat ((Rattus)) (20),Murine (18),Bovine (13),Dog (Canine) (1),Xenopus laevis (1),Zebrafish (Danio rerio) (1)
宿主
其他選擇 Rabbit
Rabbit(40),Mouse (3),Goat (1)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
Alexa Fluor 350(1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Biotin (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1),FITC (1),HRP (1)
zui低檢測(cè)濃度 0.625 ng/well
應(yīng)用范圍
其他選擇 ELISA
Western Blotting (WB)(30),ELISA (14),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Immunohistochemistry (IHC) (10),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7),Flow Cytometry (FACS) (4),Enzyme Immunoassay (EIA) (2),Immunoassay (IA) (2),Immunoprecipitation (IP) (1)
[Pubmed] 1 reference available
規(guī)格 100 μg
發(fā)貨至 中國(guó) (更改)

GNS抗體產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

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亞型 IgG
特異性 Human GNS / G6S
產(chǎn)品特性 Produced in rabbits immunized with purified, recombinant Human GNS / G6S (rhGNS, NP_002067.1, Met 1-Leu 552). Total IgG was purified by Protein A affinity chromatography.
純化方法 Affinity Purified
過(guò)濾 0.2 μm filtered

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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別名 GNS
背景 Glucosamine (N-acetyl)-6-sulfatase (GNS), also known as G6S, a hydrolase, which is one of the enzymes involved in heparan sulfate catabolism leading to lysosomal storage. GNS is required for the catabolism of the glycosaminoglycans (GAG) including heparin, heparan sulphate, and keratan sulphate through the hydrolysis of 6-sulfate group from the N-acetyl-D-glucosamine 6-sulfate units. Mucopolysaccharidosis type IIID (MPS IIID) is the least common of the four subtypes of Sanfilippo syndrome. It is caused by a deficiency of N-acetylglucosamine-6-sulphatase. A mutation in GNS resulting in MPS IIID indicates the potential utility of molecular diagnosis for this rare condition. As the least common type of the four subtypes of Sanfilippo syndrome, MPS IIID has profound mental deterioration, hyperactivity, and relatively mild somatic manifestations.
NCBI Accession NP_002067.1
研究領(lǐng)域 Proteolysis / Ubiquitin, Metabolism, Organelles

使用細(xì)節(jié)

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使用細(xì)節(jié)

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應(yīng)用備注 ELISA ELISA: 0.5-1 μg/mL This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human GNS. The detection limit for Human GNS is approximay 0.625 ng/well.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲(chǔ)存液 Without preservative
注意事項(xiàng) Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲(chǔ)存條件 4 °C/-20 °C/-80 °C
儲(chǔ)存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
有效期 12 months

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