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PCSK9抗體

抗原
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9)
別名 FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9, AI415265, AI747682, Narc1
抗原表位
其他選擇 AA 1-692
C-Term(10),N-Term (10),AA 1-691 (8),AA 151-181 (7),Internal Region (7),AA 1-694 (6),AA 1-692 (5),AA 144-173 (2),AA 454-679 (2),AA 479-508 (2),AA 152-163 (1),AA 156-461 (1),AA 164-175 (1),AA 214-228 (1),AA 35-694 (1),AA 36-55 (1),AA 490-502 (1),AA 629-692 (1),AA 679-692 (1)
適用
其他選擇 Human
Human(66),Murine (26),Rat ((Rattus)) (26)
宿主
其他選擇 Rabbit
Rabbit(60),Goat (13),Mouse (7),Rat (2)
克隆類型
多克隆
標記
其他選擇 非結(jié)合性
Biotin(4),FITC (2),HRP (2),APC (1),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Alkaline Phosphatase (AP) (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1),PE (1)
zui低檢測濃度 0.31 ng/well
應用范圍
其他選擇 ELISA
Western Blotting (WB)(51),ELISA (48),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (17),Immunohistochemistry (IHC) (12),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Flow Cytometry (FACS) (8),Immunocytochemistry (ICC) (8),Enzyme Immunoassay (EIA) (3),Immunohistochemistry (Frozen Sections) (IHC (fro)) (3),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (2),Immunoprecipitation (IP) (2),Immunoassay (IA) (1),Immunofluorescence (IF) (1)
[Pubmed] 4 references available
規(guī)格 100 μg
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PCSK9抗體

產(chǎn)品細節(jié)

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產(chǎn)品細節(jié)

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亞型 IgG
特異性 Human PCSK9
產(chǎn)品特性 Produced in rabbits immunized with purified, recombinant Human Proprotein Convertase 9 (rhPCSK9, aa 1-692, NP_777596.2). Total IgG was purified by Protein A affinity chromatography.
純化方法 Affinity Purified
過濾 0.2 μm filtered

目標詳細情況

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目標詳細情況

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別名 PCSK9
背景 Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons. < h2 id="bp_bold">
NCBI Accession NP_777596.2
研究領(lǐng)域 Proteolysis / Ubiquitin, Metabolism, Amino Acids

使用細節(jié)

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使用細節(jié)

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應用備注 ELISA ELISA: 0.5-1 μg/mL This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect PCSK9. The detection limit for PCSK9 is approximay 0.31 ng/well.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲存液 Without preservative
注意事項 Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲存條件 4 °C/-20 °C/-80 °C
儲存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
有效期 12 months

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